How to Apply – Application Guide | Grants & Funding
Summary: This document provides comprehensive instructions for preparing and submitting NIH and PHS agency grant applications using the SF424 (R&R) Forms Version I Series, effective December 2025.
The 'Research Instructions for NIH and Other PHS Agencies - Forms Version I Series' serves as the primary guidance for applicants submitting grant applications via Grants.gov. It covers the entire application lifecycle, including registration, form completion, budget development, and submission policies. The guide details specific requirements for various NIH forms, including the SF424 (R&R), PHS 398, and human subjects/clinical trials information. It also highlights significant updates for the December 2025 release, such as the implementation of the Biographical Sketch Common Form and updated indirect cost calculations.
Document outline
1. R.100 - How to Use the Application Instructions 2. R.110 - Application Process 3. R.120 - Significant Changes 4. R.130 - Program Overview 5. R.200 - SF 424 (R&R) Form 6. R.210 - PHS 398 Cover Page Supplement Form 7. R.220 - R&R Other Project Information Form 8. R.230 - Project/Performance Site Location(s) Form 9. R.240 - R&R Senior/Key Person Profile (Expanded) Form 10. R.300 - R&R Budget Form 11. R.310 - R&R Subaward Budget Attachment(s) Form 12. R.320 - PHS 398 Modular Budget Form 13. R.400 - PHS 398 Research Plan Form 14. R.500 - PHS Human Subjects and Clinical Trials Information 15. R.600 - PHS Assignment Request Form