Attachment 2 - CDC Program Announcement 05018

Federal Register / Vol. 69, No. 224 / Monday, November 22, 2004 / Notices
Dated: November 12, 2004.
Alma L. Golden,
Deputy Assistant Secretary for Population
Affairs.
[FR Doc. 04–25758 Filed 11–19–04; 8:45 am]

DEPARTMENT OF HEALTH AND
HUMAN SERVICES

BILLING CODE 4150–34–P

Cooperative Agreement Program for
the National Academic Centers of
Excellence on Youth Violence
Prevention

DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Administration on Aging
2005 White House Conference on
Aging Policy Committee
AGENCY:
ACTION:

Administration on Aging, HHS.

Notice of meeting.

SUMMARY: Pursuant to Section 10(a) of
the Federal Advisory Committee Act as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the third Policy
Committee meeting concerning
planning for the 2005 White House
Conference on Aging. The meeting will
be open to the public, with attendance
limited to space available. Individuals
who plan to attend and need special
assistance, such as sign language
interpretation or other reasonable
accommodations, should inform the
contact person listed below in advance
of the meeting.
DATES: The meeting will be held
Wednesday, December 1, 2004, from 9
a.m. to 5 p.m.

The meeting will be held at
the American Association of Homes and
Services for the Aging, 2519
Connecticut Avenue, NW., Conference
Room, Washington, DC 20008–1520.
ADDRESSES:

FOR FURTHER INFORMATION CONTACT:
Nora Andrews, (301) 443–2874, or email at [email protected].

Pursuant
to the Older Americans Act
Amendments of 2000 (Pub. L. 106–501,
November 2000), the Policy Committee
will meet to discuss delegate
participation, the conference theme, and
to review and discuss work of the
subcommittees.

SUPPLEMENTARY INFORMATION:

Josefina G. Carbonell,
Assistant Secretary for Aging.
[FR Doc. 04–25747 Filed 11–19–04; 8:45 am]
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Centers for Disease Control and
Prevention

Announcement Type: New.
Funding Opportunity Number: CE05–
018.
Catalog of Federal Domestic
Assistance Number: 93.136.
Key Dates:
Letter of Intent Deadline: December
22, 2004.
Application Deadline: February 10,
2005.
I. Funding Opportunity Description
Authority: This program is authorized
under sections 301(a) [42 U.S.C. 241(a)] and
391(a) [42 U.S.C. 280b(a)] of the Public
Service Health Act, as amended.

Purpose: The Centers for Disease
Control and Prevention (CDC)
announces the availability of fiscal year
(FY) 2005 cooperative agreement funds
to establish up to ten National
Academic Centers of Excellence (ACE)
on Youth Violence Prevention, serving
as national models for the prevention of
youth violence. The purpose of the
Centers is to help communities prevent
youth interpersonal violence. As of
2005, Centers will be supported for up
to ten years to promote a stable, long
term focus on the complex problem of
youth violence, fostering
multidisciplinary and multi-sectoral
interactions that can stimulate scientific
creativity, speed new developments in
youth interpersonal violence research
and practice, and hasten translation of
knowledge into health and community
practice. Centers are expected to
actively foster an environment
conducive to reciprocally beneficial
collaborations among health scientists,
social scientists and the affected
communities with the common goal of
reducing youth interpersonal violence.
Youth violence is defined as: The
intentional use of physical force or
power, threatened or actual, exerted by
or against children, adolescents or
young adults, ages 10–24, which results
in or has a high likelihood of resulting
in injury, death, psychological harm,
maldevelopment, or deprivation. It
includes violence between individuals
or groups who may or may not know
each other. It frequently takes place
outside the home, in the streets, or in
institutional settings, such as schools,
workplaces, and prisons. Hereafter,

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youth violence and youth interpersonal
violence will be used synonymously.
This program addresses the ‘‘Healthy
People 2010’’ focus area of Injury and
Violence Prevention. For a copy of
‘‘Healthy People 2010’’ visit the Internet
site: http://www.health.gov/
healthypeople.
Measurable outcomes of the program
will be in alignment with one (or more)
of the following performance goals for
the National Center for Injury
Prevention and Control (NCIPC):
1. Increase the capacity of injury
prevention and control programs to
address the prevention of injuries and
violence.
2. Monitor and detect fatal and nonfatal injuries.
3. Conduct a targeted program of
research to reduce injury-related death
and disability.
Special Guidelines for Technical
Assistance:
Conference Call: Technical assistance
will be available for potential applicants
during one conference call.
The call for eligible applicants will be
held on December 9, 2005 from 2:30
p.m. to 4 p.m. (eastern time). The
conference can be accessed by calling 1–
888–528–9061 and entering access code
18046.
The purpose of the conference call is
to help potential applicants:
1. Understand the Request for
Application Process for the RFA (CE05–
018) for the National Academic Centers
of Excellence on Youth Violence
Prevention.
2. Understand the scope and intent of
the RFA (CE05–018) for the National
Academic Centers of Excellence on
Youth Violence Prevention.
3. Become familiar with the Public
Health Services funding policies and
application and review procedures.
Participation in this conference call is
not mandatory. At the time of the call,
if you have problems accessing the
conference call, please call 404–639–
7550 for assistance.
Program Objectives: The goal of this
program is to reduce the incidence of
youth violence in the defined
community by achieving the following
objectives:
• Monitoring the magnitude and
distribution of youth interpersonal
violence.
• Building the scientific
infrastructure necessary to support the
development and widespread
application of effective youth violence
prevention interventions.
• Promoting interdisciplinary
research strategies to address the
problem of youth violence.
• Fostering collaboration between
academic researchers and communities.

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• Mobilizing and empowering
communities to address the problem of
youth violence.
Activities: Awardee activities during
the course of the five-year award for this
program are listed below. Additional
information on the program activities is
provided in the application content of
this announcement.
• Apply and refine a logic model for
the academic center of excellence
adapted from the national ACE Program
conceptual framework or logic model
(See Appendix 1 for a description) to fit
the specific inputs, activities, outputs,
and outcomes of the proposed center.
• Develop and implement a center
evaluation plan and demonstrate how
the center’s evaluation contributes to
CDC’s national program evaluation,
including the core performance
indicators (see Appendix 2 for a list of
the indicators.)
• Develop, implement and evaluate
center projects in conjunction with the
center’s ‘‘defined community’’, (whether
geographic or a non-geographic subgrouping) which the center’s activities
will serve. Community is defined as a
group of people who share some or all
of the following: geographic boundaries;
a sense of membership; culture and
language; common norms, interests, or
values; and common health risks or
conditions (CDC/ATSDR Principles of
Community Engagement, IOM 2002).
Community refers to a population that
has a distinct identity. It can mean
residents of a geographic area, be that a
catchment’s area, neighborhood, school
district, city, county or region within a
county. It can be used with a modifier
or clause to describe a nongeographically based sub-grouping such
as, but not exclusively: a community of
youth violence prevention workers, a
community of health professionals, or
an ethnic or language community.
• Establish or maintain a center
community advisory committee to work
with the defined community to achieve
center goals. See Appendix 3, the
glossary, for a definition and
composition of the community
committee.
• Establish and maintain partnerships
(e.g., state and local health departments,
youth violence prevention and youth
serving organizations, community
groups and agencies, faith-based
organizations and local businesses, and
academic units), and include these
partners, when applicable, in the center
activities. See Appendix 3, the glossary,
for a definition and composition of
partnerships.
• Establish and/or enhance
surveillance systems to better measure
the problem of youth violence and the

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impact of center activities and research
in the defined community.
• Identify youth violence prevention
priorities within the defined
community.
• Carry out the center’s participatory,
community-based core youth
interpersonal violence research
project(s) and the center’s five-year
research agenda. Each center is required
to conduct at least one core research
project consistent with both the NCIPC
Research Agenda and NCIPC’s mission.
• Plan the core research project in
collaboration with community partners.
• Refine, carry out and evaluate the
center’s community mobilization plan
in partnership with a community’s
individuals, groups, and organizations
on a participatory and sustained basis.
(See Appendix 3, the glossary, for a
definition of community mobilization.)
• When appropriate, collaborate with
CDC, community partners, and other
ACE centers to develop and finalize
design for studies and activities,
methodology, data collection measures,
methods, and analyses and disseminate
the results through presentations and
publications to broad audiences,
including public health.
• Collect and report necessary data
and information to CDC to assess
progress toward centers’ goals and
objectives and monitor overall
performance. This should include, but
will not be limited to, information
related to the ACE Performance
Indicators. (See Appendix 2 for list of
indicators).
• Develop an infrastructure of
personnel and resources to support
center functions and processes. This
infrastructure should ensure that
adequate personnel, facilities,
technology, and university support
exists to accomplish the goals and
objectives of the center.
• Provide training, technical
assistance, and mentoring to health
professionals, researchers, students,
community members, and other
partners, as appropriate, including other
funded Academic Centers of Excellence
on Youth Violence Prevention.
• Obtain approval of the study
protocol by the recipient’s local
Institutional Review Board (IRB).
Collaborate with CDC in the
development of a research protocol for
CDC Institutional Review Board (IRB)
review, if appropriate.
In a cooperative agreement, CDC staff
is substantially involved in the program
activities, above and beyond routine
grant monitoring. CDC activities for this
program are as follows:
• Provide scientific input, serve as a
scientific and professional resource, and

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collaborate with ACE staff on research,
interpretation of findings, and the
production of publications and
presentations to disseminate study
results.
• Facilitate regular communication
between CDC and the grantees to
include, but not limited to conference
calls and meetings, including the
convening of annual ACE meetings to
facilitate research collaboration and
information sharing among centers.
• Review, monitor, and evaluate
scientific and operational
accomplishments to assure progress
toward program goals and objectives.
The review will be based on the center’s
logic model and the critical components
of the model that are related to the
achievement of core performance
indicators. The review process will
include but not be limited to conference
calls, site visits, annual meetings, and
required reports.
• Collect, organize and disseminate
information on ACE activities, including
research. Inform recipients about any
CDC policies, laws, and regulations
pertaining to public health research and
programmatic activities, conduct
inquiries concerning allegations of
scientific misconduct, and take
necessary steps to bring program into
compliance.
• When appropriate, assist in the
development of a research protocol(s)
for IRB review by all performance sites
involved in the research project. If CDC
researchers are significantly involved in
the project, the CDC IRB will review and
approve the protocol initially and on at
least an annual basis until the research
project is completed.
II. Award Information
Type of Award: Cooperative
Agreement. CDC involvement in this
program is listed in the Activities
Section above.
Mechanism of Support: U49.
Fiscal Year Funds: 2005.
Approximate Total Funding:
$6,800,000 (This amount is an estimate,
and is subject to availability of funds).
Approximate Number of Awards: 7–
10.
Approximate Average Award:
$830,000.
Floor of Award Range: $680,000.
Ceiling of Award Range: $980,000
(Ceilings are for the first 12-month
budget period and include both indirect
and direct costs).
Anticipated Award Date: September
1, 2005.
Budget Period Length: 12 months.
Project Period Length: Five years.
Throughout the project period, CDC’s
commitment to continuation of awards

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will be conditioned on the availability
of funds, evidence of satisfactory
progress by the recipient (as
documented in required reports and site
visits), and the determination that
continued funding is in the best interest
of the Federal Government.
III. Eligibility Information
III.1. Eligible Applicants
Eligible applicants are academic
institutions/centers with a focus on
health, such as:
• Public and private nonprofit
universities;
• Colleges;
• University-associated teaching
hospitals.
Eligible applicants may enter into
contracts, including consortia
agreements, as necessary to meet the
requirements of the program and
strengthen the overall application. A
Bona Fide Agent is an agency/
organization identified by the academic
institutions/centers as eligible to submit
an application under the academic
institutions/centers eligibility in lieu of
an academic institutions/centers
application. If you are applying as a
bona fide agent of academic
institutions/centers, you must provide a
letter from the academic institutions/
centers as documentation of your status.
Place this documentation behind the
first page of your application form.
III.2. Cost Sharing or Matching
Matching funds are not required for
this program announcement.
III.3. Other
CDC will not accept and review
applications with budgets greater than
the ceiling of the award range.
Applications with budgets that exceed
the ceiling of the award, which includes
both direct and indirect costs, will be
considered non-responsive, and will not
be entered into the review process. You
will be notified that your application
did not meet the submission
requirements.
Special requirements: If your
application is incomplete or nonresponsive to the requirements listed in
this section, it will not be entered into
the review process. You will be notified
that your application did not meet
submission requirements.
• Late applications will be considered
non-responsive. See section ‘‘IV.3
Submission Dates and Times’’ for more
information on deadlines.
A National Academic Center of
Excellence on Youth Violence
Prevention is expected to have the
following core components which

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together address the objectives of a
center: (1) Administrative and
Infrastructure Core, (2) Surveillance and
Research Core and (3) Outreach and
Education Core. The essential
characteristics of a National Academic
Center of Excellence on Youth Violence
Prevention are as follows:
• A core faculty in fields such as
public health, epidemiology,
biostatistics, social sciences, behavioral
and environmental sciences, health and
youth policy, economics, evaluation,
and health administration.
• Established working relationships
with multidisciplinary faculty in the
fields listed above and in other
disciplines, such as, but not limited to,
medicine, psychology, nursing, social
work, education, urban planning, youth
development and business.
• Graduate training programs relevant
to youth violence prevention.
• Demonstrated relationships with a
broad range of community partners and
expertise in developing, implementing
and evaluating community-based youth
participatory research and mobilization
activities.
• Demonstrated experience on the
applicant’s project team in conducting,
evaluating, and publishing communitybased participatory research (CPBR) in
peer-reviewed journals. (See Appendix
3, the glossary, for a definition of
Community-based participatory
research).
• Effective and well-defined working
relationships within the performing
organization and with outside entities
(as evidenced by letters of support and
in memoranda of understanding).
• An overall match between the
applicant’s proposed research objectives
and the program objectives as described
under the heading, ‘‘Program
Objectives’’.
Only one application per institution
will be accepted.
Note: Title 2 of the United States Code
section 1611 states that an organization
described in section 501(c)(4) of the Internal
Revenue Code that engages in lobbying
activities is not eligible to receive Federal
funds constituting an award, grant, or loan.

Individuals Eligible To Become
Principal Investigators
Principal Investigator qualifications
are as follows:
• A principal investigator who has
conducted community-based youth
violence prevention research, published
the findings in peer-reviewed journals,
and has specific authority and
responsibility to carry out the proposed
project.

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Applications that do not meet the
above requirements will be considered
non-responsive.
Individuals with the above-listed
skills, knowledge, and resources
necessary to carry out the proposed
research are invited to work with their
institution to develop an application for
support. Individuals from
underrepresented racial and ethnic
groups as well as individuals with
disabilities are always encouraged to
apply for CDC programs. Each
institution may submit only one
application per round of competition.
IV. Application and Submission
Information
IV. 1. Address To Request Application
Package
To apply for this funding opportunity,
use application form PHS 398 (OMB
number 0925–0001 rev. 5/2001). Forms,
attachments and instructions are
available in an interactive format on the
CDC Web site, at the following Internet
address: http://www.cdc.gov/od/pgo/
forminfo.htm.
Forms and instructions are also
available in an interactive format on the
National Institutes of Health (NIH) Web
site at the following Internet address:
http://grants.nih.gov/grants/funding/
phs398/phs398.html.
If you do not have access to the
Internet, or if you have difficulty
accessing the forms on-line, you may
contact the CDC Procurement and
Grants Office Technical Information
Management Section (PGO–TIM) staff
at: 770–488–2700. Application forms
can be mailed to you.
IV. 2. Content and Form of Application
Submission
Letter of Intent (LOI): Prospective
applicants are asked to submit a Letter
of Intent (LOI) that includes the
following information and written in the
following format:
• Maximum Number of Pages: Three.
• Font Size: 12-point unreduced.
• Paper Size: 8.5 by 11 inches.
• Page Margin Size: One inch.
• Printed only on one side of page.
• Single spaced.
• Written in plain language, avoid
jargon.
Your LOI must contain the following
information:
• Descriptive title of the proposed
Center.
• Name, address, e-mail address,
telephone number, and facsimile
number of the Principal Investigator.
• Names of other key personnel.
• Participating institutions.
• Number and title of this RFA.

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• Brief description of the proposed
center’s research focus (a three to four
line description).
• Brief description of the scope and
intent of the proposed center work
(maximum one paragraph).
Note: Attachments, booklets, or other
documents will not be accepted with the LOI.

Application: Follow the PHS 398
application instructions for content and
formatting of your application. If the
instructions in this announcement differ
in any way from the PHS 398
instructions, follow the instructions in
this announcement. For further
assistance with the PHS 398 application
form, contact PGO–TIM staff at 770–
488–2700, or contact GrantsInfo,
Telephone (301) 435–0714, e-mail:
[email protected].
Your application should address
activities to be conducted over the
entire five-year project period.
For more information, see the CDC
Web site at: http://www.cdc.gov/
funding.htm.
This announcement uses just-in-time
concepts. This announcement uses the
non-modular budgeting format. The
application narrative should consist of
the following information:
(1) Administrative and Infrastructure
Core: To ensure that applicants have the
administrative and infrastructure
capacity to achieve the program
objectives, applicants should describe
the following:
(a) Defined Community: Applicants
need to define and describe the center’s
mission and the primary community
(whether geographic or a nongeographic sub-grouping) that the
center’s activities will serve. (See
Appendix 3, Glossary of Terms, for a
definition of community). Applicants
should, at a minimum, address the
following characteristics of the defined
community, as they pertain to the type
of community chosen: the size of the
community; the demographic make up,
socioeconomic and cultural
characteristics; levels of youth violence
and the prevalent risk and protective
factors of, or encountered by, the
defined community; the youth violence
prevention infrastructure, levels of
organization and support for
interpersonal youth violence prevention
interventions in the defined community;
and the existence of health, education,
justice, and other policies related to
youth violence prevention in the
defined community. Applicants should
describe the linkages between the center
and the defined community and
document appropriate levels of
engagement and collaboration that

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reflects the ability to carry out proposed
center activities.
(b) Evaluation: Applicants need to
describe how they will develop a plan
for evaluating the progress of the center
in achieving its goals and the national
performance indicators. Applicants
should describe their capacity to:
establish a five-year evaluation plan;
conduct center-level evaluation; and
collect data to determine the
performance of the center using the
national performance indicators. (See
Appendix 2 for a description of
Developing an Evaluation Framework:
National Academic Centers of
Excellence in Youth Violence
Prevention.) To assure that applicants
have this capacity, applicants should, at
a minimum:
(i) Describe their center-level logic
model specifying the center’s youth
violence prevention priorities and
expected outcomes. Within the logic
model, applicants should define the
inputs, activities, outputs, outcomes,
evaluation, and contextual conditions
for the center. The logic model should
be adapted from the national ACE
Program conceptual framework (See
Appendix 2.) In addition to the logic
model, a narrative description of each
component must be included. Please
include the center’s mission within the
narrative, limiting the mission statement
to one to two sentences. Further, within
this narrative briefly describe how the
center’s model is related to the national
ACE Program conceptual framework.
(ii) Document experiences of center
faculty in conducting process,
outcomes, and impact evaluations in the
past five years and address how the
center will continue or enhance its
evaluation expertise as it relates to the
center-level evaluation.
(iii) Describe how they will create a
five-year plan for evaluating the critical
components of the center’s logic model.
The plan should be developed in
collaboration with the center’s
community committee and center
partners and include: a description of
how the plan will be developed;
identification of resources and staff
responsible for evaluation; specific
evaluation questions, goals and
objectives; quantitative and qualitative
assessment of the centers activities to
demonstrate program accomplishments
and challenges; and a plan for
identifying emerging challenges.
(c) Infrastructure: Applicants should
describe an infrastructure of personnel
and resources required to develop
center functions and processes.
Applicants should have the capacity to
recruit, hire, and retain faculty and staff
with the expertise to implement center

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projects and activities; acquire, manage,
and maintain the communications and
information systems necessary to
operate an ACE; and acquire and
maintain university support for the
center. To assure that applicants have
this capacity, applicants should, at a
minimum:
(i) Provide an organizational chart for
the center showing all organizational
units and functions. The chart should
also reflect the activities articulated in
the center’s logic model.
(ii) Describe the center’s staffing and
management plan. Describe each
proposed position and discuss how the
position provides the scientific and
technical expertise needed to carry out
both research and non-research
activities. Describe the minimum
criteria and the required expertise for
each position. Describe the
qualifications of the proposed staff, how
the proposed staff will interact with
each other, with other faculty outside
the center, and with the university’s
leaders to accomplish the center’s goals
and objectives. This discussion should
highlight the following center staff:
leadership; research; evaluation;
communication and dissemination;
training; information management; and
fiscal and administration staff.
(iii) Describe how your center will be
integrated within the university
structure. Describe the facilities in
which staff will work and how these
facilities enhance the center’s ability to
complete the proposed activities.
Describe the center’s plan to enhance its
core capacity over the five-year period,
including the commitment and
capability to obtain the communication,
information systems, and other tools
necessary to accomplish goals and
objectives (i.e., computer equipment,
telephones, facsimile machines,
scanners, scientific software, etc.).
(iv) Describe plans for crossdisciplinary training of new and
established investigators, including:
adequacy of facilities for workshops,
seminars and other educational
activities; capacity to train predoctoral
and/or postdoctoral students in multidisciplinary interpersonal youth
violence prevention research; and
experience in effectively conducting
mentoring and career development
activities.
(d) Collaborations/Partnerships:
Applicants need to develop and
describe the nature and range of
partnerships needed to carry out center
activities. An infrastructure of resources
and personnel is required to support
collaboration with partners and joint
community mobilization efforts. (See
Appendix 3, Glossary of Terms, for an

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operational definition). Applicants
should have the capacity to: Establish
and maintain relationships with
partners; facilitate the establishment
and maintenance of the center’s
community committee(s); and
collaborate with partners on the
planning and implementation of core
research, dissemination, training, and
mobilization efforts. To assure that
applicants have this capacity, applicants
should:
(i) Describe the plan for establishing
or maintaining the center’s community
committee(s). (See Appendix 3, Glossary
of Terms for additional information
regarding the center community
committee.) This plan should include,
at a minimum, the following: The
intended composition and membership
of the committee and how the
constituents reflect the defined
community; the proposed mission and
role for the committee in the center’s
planning and activities, consistent with
the logic model; a process for
developing or refining guidelines for the
community committee over the first
year of the funding period; a plan for
communication between the community
committee and the center staff.
Applicants must provide evidence of
commitment and cooperation of current
and potential members of the center’s
community committee (e.g., letters of
support, memorandums of
understanding, or examples of prior
collaboration.)
(ii) Identify and describe other
partners such as local and state health
departments, youth violence prevention
organizations, community groups and
agencies, youth organizations, and
academic units. At a minimum,
applicants need to briefly describe: Past
partners, new partners, and proposed
partners; the proposed methods for
establishing and maintaining these
partnerships, including how the lessons
learned from previous partnerships will
be applied to the proposed methods;
and the partners’ involvement in the
center’s proposed activities. In this
section, applicants should specifically
address the partners’ role in developing
this proposal and partners’ expectations
about their roles in the planning and
implementation of the center’s
activities.
(iii) Provide evidence of commitment
and cooperation of current and potential
partners (e.g., letters of support,
memorandums of understanding, and
examples of prior collaborations).
2. Surveillance and Research Core:
Applicants need to describe and
develop the infrastructure of resources
and personnel required to support
surveillance and research in the center.

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Applicants need to enhance
surveillance efforts and conduct
research, as described below:
(a) Surveillance: Applicants should
document experience in successfully
developing, implementing and
evaluating community level
surveillance efforts in the last five years
and describe plans to develop and/or
enhance surveillance systems to be able
to measure the problem of youth
violence as well as determine impact of
Center activities and research in the
defined community. Applicants should
address how your system will: Measure
youth violence patterns in the defined
community; be used to guide planning
and evaluation of youth violence
programs (e.g., determine in what
components and areas where prevention
efforts are making a difference); and
advance the public health research
related to youth violence. All proposed
surveillance activities should include an
appropriate translation and
dissemination plan. To assure that
applicants have this capacity, applicants
should, at a minimum: Document
experience in successfully developing,
implementing and evaluating
community level surveillance efforts in
the last five years.
(b) Research: Applicants should
describe center capacity to: Establish a
five-year research agenda; conduct core
research and other prevention research
as described in the research agenda; and
effectively collaborate with partners in
the identification, planning,
implementation, and dissemination of
core research. To assure that applicants
have this capacity, applicants should, at
a minimum: Document experience in
successfully conducting, evaluating, and
publishing youth interpersonal violence
prevention research in the past five
years; and describe community-based
youth interpersonal violence prevention
research activities and provide evidence
of community involvement in those
activities; and describe experience in
conducting community-based
participatory research in the past five
years.
Applicants should describe (the core
elements of) a five year research agenda,
including a description of the core
youth interpersonal violence prevention
research project(s), and smaller studies
and seed projects, as described below.
The research projects and the agenda
should reflect the potential for a center
with a clear mission that promotes
multidisciplinary collaboration and
career development. The research
agenda must represent more than an
interesting collection of projects.
Research projects must be
interdependent (materials, results, data,

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or methodologies are shared among the
projects), interrelated (each project must
have goals and objectives that focus on
the common theme), and
multidisciplinary (representing different
scientific backgrounds, training and
expertise). Centers must develop
research projects on youth interpersonal
violence prevention with a conceptual
focus on the defined community and
that provide evidence of the potential
for meaningful inter-disciplinary
collaboration, and that respond to the
NCIPC Research Agenda. Clear
definitions of procedures used to select
proposed and future projects are
required.
The core research project should
address the following types of applied
interpersonal youth violence prevention
research articulated in the NCIPC
Research Agenda and that furthers the
center’s work in the defined
community: intervention research,
which examines the efficacy,
effectiveness, economic efficiency of
strategies, programs and policies in
reducing or preventing youth
interpersonal violence; and
dissemination and dissemination
implementation research (which
includes research on the targeted
distribution of information to a specific
audience; and research on the use of
strategies to introduce or change
evidence-based youth interpersonal
violence prevention interventions in
specific settings).
Applicants should also demonstrate
the links to the community within
which the research is framed,
documenting appropriate levels of
support and collaboration. If the
research agenda is also supported by
non-ACE Program funding sources,
identify the other funders.
The types of research projects centers
are expected to carry out are listed
below:
(i) Core research projects are the larger
scale projects with annual budgets
exceeding 150,000 a year, including
direct and indirect costs, and lasting up
to five years. These projects typically
will test hypotheses and employ more
sophisticated methodologies and/or
larger sample sizes than small studies.
Core research projects require an RO1
level summary as described in PHS 398
(Revised 5/01 and updated 6/28/02)
guidelines.
(ii) Small studies of 25,000–150,000 a
year, including direct and indirect costs,
for one to three years duration, might be
extensions of seed projects, either
further developing methods or
hypotheses in preparation for a larger
investigation, or might be stand alone
investigations sufficient to yield results

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worthy of publication in a peerreviewed journal and/or a technical
report for a legislative body,
governmental agency or youth violence
prevention organizations.
(iii) Seed projects, under 25,000
require a short write-up describing the
youth interpersonal violence prevention
context of the study, the objective, the
design, the setting and participants, the
intervention being addressed, main
outcome measurements, expected
results, timelines, costs.
The applicant should use the
following template to describe each
proposed research project:
• Title of the project.
• Project Director/Lead Investigator
for the project.
• Institution(s)/partners involved in
the project.
• Categorization of the type of
research (such as, but not exclusively,
intervention, dissemination, and
dissemination-implementation
research).
• Relationship of the project to the
center’s mission and health priorities.
• Relationship of the project to local
youth interpersonal violence prevention
priorities, HHS objectives (e.g., Healthy
People 2010), and NCIPC Research
Agenda.
• Indication of whether the project is
new or ongoing. (If ongoing, describe
the prior work on this project.)
• Evidence of community
participation in the planning,
implementation, and evaluation of the
project. Describe how the center will
collaborate with partners on refining
and developing the research
methodology, recruiting of research
participants, and reporting and
disseminating research findings.
• Summary of the research project:
(i) Background
(ii) Importance
(iii) Relevance to the defined
community.
(iv) Integration into 5 year research
agenda
(v) Goals and objectives
(vi) Proposed timeframe for the project
(vii) Setting and context
(viii) Methods and measures
(ix) Study participants and recruitment
strategy. Provide evidence that the
recipient (or a collaborating partner)
has access to the study population
and that the participation by the study
population will be adequate to test
hypotheses.
(x) Expected outcomes
(xi) Communication and dissemination
Data Sharing and Release: Describe
plans for the sharing and release of data,
if applicable (See AR–25 for additional
information).

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3. Outreach and Education Core: To
ensure that applicants have the capacity
to achieve the outreach and education
program objectives, applicants should
describe the following:
(a) Community Mobilization:
Applicants need to describe a draft plan
for community mobilization. Applicants
should describe the infrastructure of
resources and personnel to support
community mobilization activities in
the center and to develop and
implement a community mobilization
plan involving the primary community
the center’s activities will serve. For a
definition of Community Mobilization
and Community Mobilization Plan
(CMP), see Appendix 3, Glossary of
Terms. The two overriding goals of a
community mobilization plan should be
to: enhance the community’s capacity to
address the problem of youth violence
and prevent or reduce youth violence.
(For additional Guidance on how to
develop a CMP, see: http://
www.phppo.cdc.gov/dphsdr/
documents/MAPPone_pager.doc and
http://mapp.naccho.org/
mapp_introduction.asp).
Applicants should have the capacity
to: establish a five-year community
mobilization plan (CMP); conduct
community mobilization activities as
required in the CMP; and effectively
collaborate with partners in the
identification, planning,
implementation, and evaluation of the
CMP. In addition, the CMP should
provide evidence that applicant or their
collaborating partners have access to the
defined community population, and
that the participation by the defined
community population will be adequate
to develop, implement and evaluate the
plan.
To assure that applicants have this
capacity, applicants should at a
minimum:
(i) Provide evidence of having
identified youth interpersonal violence
prevention priorities, including
disparities, within the defined
community and of having identified
them in collaboration with community
partners.
(ii) Document experience in
successfully developing, conducting,
and evaluating community mobilization
activities in the past five years.
(iii) Describe how the CMP helps
fulfill the center’s mission. If the
community mobilization efforts are also
supported by non-ACE Program
collaborations, identify the other
funders.
(iv) Describe the center’s draft fiveyear CMP, including the goals and
objectives. The applicant should use the
following template and provide

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information to describe the community
mobilization plan:
• Title of the plan;
• Core staff and community partners;
• Institution(s)/partners involved in
the project;
• Indication of whether the
community mobilization plan is new or
ongoing. (If ongoing, describe the prior
work on this plan.)
• Describe how the center will
collaborate with partners: In the
refinement of the CMP, in the
development of the community
mobilization methodology, for
community recruitment, to report and
disseminating information and
activities, and to evaluate CMP
outcomes.
• Summary of the Community
Mobilization Plan.
This should include:
(i) Background;
(ii) How the plan furthers the defined
community youth violence prevention
needs, and priorities;
(iii) Describe how the CMP is
integrated into the center’s five-year
research agenda and the centers
mission;
(iv) Goals and objectives;
(v) Proposed timeframe for the plan;
(vi) Setting and context;
(vii) Methods and measures;
(viii) Community definition,
participation and recruitment strategy;
(ix) Expected outcomes;
(x) Communication, dissemination,
and evaluation.
(b) Communication and
Dissemination Activities: Applicants
should outline how they will develop a
communication plan and describe the
communication and dissemination
infrastructure and activities to be
carried out to further the program goals.
Applicants should have the capacity to:
disseminate research by making its
findings, methods, and tools available;
keep stakeholders (i.e., researchers,
practitioners, community members, and
policymakers) abreast of the center’s
accomplishments; produce products
that reflect research progress and
results, and participate in coordinated
activities with other ACEs and their
collaborating partners (e.g., state/local
health departments, community groups,
and youth violence prevention research
and practice organizations) to facilitate
linkages among ACEs and national/
state/local partners to ensure National
Program objectives are being achieved.
To assure that applicants have this
capacity, applicants should, at a
minimum:
(i) Outline how a communication plan
will be developed that defines and

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describes how the center’s
communication and dissemination
activities will be integrated into the
center’s activities, including the
research agenda.
(ii) Address how the center will work
with collaborators and other partners to
extend the center’s reach; how the
center’s activities and research will
affect youth violence prevention
policies impacting their community;
and how other potential outcomes
through communication and
dissemination efforts will be identified.
(iii) Describe the methods the center
will use to translate, communicate, and
disseminate its products and other
information. Address how the center
will produce, translate and distribute
publications and materials such as
scientific papers, conference reports,
newsletters, and educational and
training materials; plan proposed
meetings, personal interactions, and
sharing of information with
collaborators for the development of
long-term partnerships; provide
electronic dissemination of products
and other information through websites
and any other means; and develop
media releases and statements, or
pursue opportunities for media
coverage.
(iv) Describe the center’s
infrastructure of resources and
personnel that will support the
identified communication and
dissemination activities. At a minimum,
describe the center’s ability to:
disseminate community-based youth
violence prevention research in public
health, allied disciplines and the
constituent communities/stakeholders;
translate the content of the center’s
activities for different audiences;
develop a plan that reflects the
community’s youth demographic and
cultural profile; and access personnel
and resources, as applicable for layout
and design, web site construction,
photography, proofreading, and other
development and production activities.
(c) Training, Technical Assistance
and Mentoring: Applicants should
describe the center’s draft plan for
providing training, technical assistance,
and mentoring, and the infrastructure of
resources and personnel required to
support training, technical assistance,
and mentoring of practitioners,
researchers, students, community
members, and other partners, as
applicable. Applicants should have the
capacity to assess, plan, implement, and
evaluate training, technical assistance,
or mentoring activities. Applicants, at a
minimum, should address the
following:

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(i) Describe the center’s assets or
needs assessment (past, current, or
proposed) for training, technical
assistance, and mentoring. Explain
collaboration with partners in the assets
and needs assessment.
(ii) Describe the center’s draft plan for
providing training, technical assistance,
and mentoring. This plan should
include: goals and objectives; partner
collaboration; and how the plan reflects
the mission of the center and the assets
and needs assessment described above.
Describe how any lessons learned from
prior training; technical assistance and
mentoring activities during the past five
years will be applied to the proposed
plan. Additionally, describe training
facilities and resources (e.g., ability to
print materials, use video and computer
equipment, and develop Web sites).
(iii) Describe the opportunities and
quality of the career development and
mentoring plan for the junior
investigators in the center. Applicants
should describe the feasibility and
potential for junior investigators to gain
research experience in youth violence
affecting at-risk populations.
The narrative should be no more than
100 pages (8.5″ × 11″), double-spaced,
and printed on one side only, with oneinch margins on all sides and
unreduced 12-point font. Appendices
must be hard copy documents (i.e., no
audiovisual materials or posters).
In order to facilitate the preparation
and review of the application, the
application components should be
organized according to the Table of
Contents listed below. The table of
contents below supersedes the
instructions contained in the PHS 398.
• Detailed Budget for the Initial
Budget for the Entire Proposed Period
for Each Project.
• Budget for the Entire Proposed
Period of Support for the Entire
Proposed Center.
• Detailed Budget Justification for
Each Proposed Project/Activity for the
Initial Budget Period.
• Biographical Sketch-Principal
Investigator/Program Director.
• Other Biographical Sketches.
• Other Research Support.
• Executive Summary with Overall
Goals and Objectives of the Center.
• Center Logic Model.
• Application Narrative:
Overall Description of the Proposed
Center.
Statement on the Institutional
Commitment to the Proposed Center.
Performance/Accomplishments in
Last Project Period (Current Centers).
Past Performance/Accomplishments
Relevant to Proposed Center.
Administrative and Infrastructure
Core: Defined Community; Evaluation;

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Infrastructure; Collaborations/
Partnerships.
Surveillance and Research Core:
Surveillance Projects; Core Research
Projects; Seed Projects.
Outreach and Education Core:
Community Mobilization;
Communication and Dissemination
Activities: Training, Technical
Assistance, and Mentoring.
The RFA label available in the PHS
398 (rev. 5/2001) application form must
be affixed to the bottom of the face page
of the application.
IV.3. Submission Dates and Times
LOI Deadline Date: December 22,
2004.
CDC requests that you send a LOI if
you intend to apply for this program.
Although the LOI is not required, not
binding, and does not enter into the
review of your subsequent application,
the LOI will be used to gauge the level
of interest in this program, and to allow
CDC to plan the application review.
Application Deadline Date: February
10, 2005.
Explanation of Deadlines:
Applications must be received in the
CDC Procurement and Grants Office by
4 p.m. eastern time on the deadline
date. If you send your application by the
United States Postal Service or
commercial delivery service, you must
ensure that the carrier will be able to
guarantee delivery of the application by
the closing date and time. If CDC
receives your application after closing
due to: (1) carrier error, when the carrier
accepted the package with a guarantee
for delivery by the closing date and
time, or (2) significant weather delays or
natural disasters, you will be given the
opportunity to submit documentation of
the carriers guarantee. If the
documentation verifies a carrier
problem, CDC will consider the
application as having been received by
the deadline.
This announcement is the definitive
guide on application submission
address and deadline. It supersedes
information provided in the PHS 398
application instructions. If your
application is not received in the CDC
Procurement and Grants office by the
deadline above, it will not be eligible for
review, and will be discarded. You will
be notified that you did not meet the
submission requirements.
CDC will not notify you upon receipt
of your application. If you have a
question about the receipt of your
application, first contact your courier.
CDC will not notify you by mail upon
receipt of your application, but if you
still have any questions, contact the
PGO–TIM staff at: 770–488–2700. Before

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calling, please wait two to three days
after the application deadline. This will
allow time for applications to be
processed and logged.
IV.4. Intergovernmental Review of
Applications
Executive Order 12372 does not apply
to this program.
IV.5. Funding Restrictions
Restrictions, which must be taken into
account while writing your budget, are
as follows:
• Funds relating to the conduct of
research will not be released until the
appropriate assurances and Institutional
Review Board approvals are in place.
If you are requesting indirect costs in
your budget, you must include a copy
of your indirect cost rate agreement. If
your indirect cost rate is a provisional
rate, the agreement must be less than 12
months of age.
IV.6. Other Submission Requirements
LOI Submission Address: Submit your
LOI by express mail, delivery service,
fax or e-mail to:
Address for Express Mail or Delivery
Service: NCIPC Extramural Resources
Team, CDC, National Center for Injury
Prevention and Control, 2945 Flowers
Road, Yale Building, Room 2054,
Atlanta, Georgia 30341.
Address for U.S. Postal Service Mail:
NCIPC Extramural Resources Team,
CDC, National Center for Injury
Prevention and Control, 4770 Buford
Hwy, NE., Mailstop K–62, Atlanta, GA
30341, telephone: 770–488–4037, fax:
770–488–1662, e-mail: [email protected].
Application Submission Address:
Submit the original and one copy of
your application by mail or express
delivery service to: Technical
Information Management CE05–018,
CDC Procurement and Grants Office,
2920 Brandywine Road, Atlanta, GA
30341.
At the time of submission, four
additional copies of the application, and
four copies of all appendices must be
sent to:
Address for Express Mail or Delivery
Service: NCIPC Extramural Resources
Team, CDC, National Center for Injury
Prevention and Control, 2945 Flowers
Road, Yale Building, Room 2054,
Atlanta, Georgia 30341.
Address for U.S. Postal Service Mail:
NCIPC Extramural Resources Team,
CDC, National Center for Injury
Prevention and Control, 4770 Buford
Hwy, NE., Mailstop K–62, Atlanta, GA
30341.
Applications may not be submitted
electronically at this time.

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V. Application Review Information
V.1. Criteria
Applicants are required to provide
measures of effectiveness that will
demonstrate the accomplishment of the
objectives identified in the cooperative
agreement. Measures of effectiveness
must relate to the performance goals
stated in the ‘‘Purpose’’ section of this
announcement. Measures must be
objective and quantitative, and must
measure the intended outcome. These
measures of effectiveness shall be
submitted with the application and
shall be an element of evaluation.
The goals of CDC-supported research
are to advance the understanding of
biological systems, improve the control
and prevention of disease and injury,
and enhance health. In the written
comments, reviewers will be asked to
evaluate the application in order to
judge the likelihood that the proposed
research will have a substantial impact
on the pursuit of these goals.
The scientific review group will
address and consider the following
items in the determination of scientific
merit.
1. Administrative and Infrastructure
Core (Total: 150 points)
(a) Defined Community (25 points).
To what extent does the applicant
adequately define and describe the
primary community that the center’s
activities serve, such as: (i) The size of
the defined geographic or nongeographic community, (ii)
characteristics such as demographic
make up, socioeconomic, and cultural
characteristics, (iii) levels of youth
violence and a description of the
prevalent risk and protective factors, (iv)
the youth violence prevention and
public health infrastructure, including
levels of organization and support for
interpersonal youth violence prevention
and community health interventions, (v)
community assets and history of
‘‘community participation, (vi) existing
health, education, community, justice
and other local policies related to youth
violence prevention. How well does the
applicant describe the center links to
the defined community and document
appropriate levels of engagement and
collaboration?
(b) Program Evaluation (50 points). To
what extent does the applicant: (i)
Appropriately describe the center-level
logic model and provide a narrative
description of components of the logic
model, (ii) sufficiently describe and
justify how each component of the
center’s logic model relates to or
differentiates from the national ACE
Program conceptual framework, (iii)
describe relevant evaluation experiences

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and expertise as it relates to conducting
an evaluation of the applicant’s center,
(iv) articulate a five-year evaluation plan
for evaluating the critical components of
the center’s logic model, including the
goals and objectives, and (v) illustrate
how the center’s evaluation plan is
related to the national ACE Program
evaluation activities, which includes
annual reporting on national
performance indicators.
(c) Infrastructure (25 points). To what
extent does the applicant: (i) Provide a
detailed organizational chart that
represents the center’s activities, (ii)
describe how the organizational
structure facilitate the center’s activities,
(iii) describe the positions needed to
accomplish the center’s goals and
objectives, (iv) propose a staffing plan
with the required experience, expertise,
and percentage of effort among the
center’s leadership, research,
evaluation, communications, training,
information management, and fiscal
administration staff to accomplish its
proposed goals and objectives, (v)
explain how it will increase its capacity
over time, (vi) demonstrated the
applicant’s commitment to the center
(e.g., facilities, technological resources,
etc.)and adequate university
commitment to establish and maintain
an identity for the proposed center.
Is sufficient documentation of
institutional endorsement of the
proposed five-year research and
community mobilization plans offered,
including: (i) Letters of commitment
from senior institutional officials from
both collaborating institutions, (ii)
letters of support that fully address and
support the priorities and objectives of
the center.
(d) Collaborations/Partnerships (50
points). To what extent does the
applicant: (i) Describe the center’s
community advisory committee,
particularly its initial mission, roles,
composition, and plans for developing
or refining guidelines, (ii) provide
letters of support or other evidence from
these partners of active participation in
this collaboration that fully address and
support the priorities and objectives of
the center, (iii) outline the past and
newly established partnerships, the
roles of these partners, and the methods
for establishing and maintaining the
partnerships, and (iv) articulate the
proposed activities with the identified
partners?
2. Surveillance and Research Core
(Total: 200 Points)
(a) Surveillance (50 points). To what
extent does the applicant: (i) Describe
the establishment and/or enhancement
of surveillance system(s) to be able to
measure the problem of youth violence

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in the chosen community, (ii) address
how these efforts will lead to a better
understanding of factors influencing
youth violence prevention, and (iii)
include an appropriate translation and
dissemination plan for the proposed
surveillance activities?
(b) Research (150 points). To what
extent does the applicant:
(i) Describe the research project(s)
linkage to the center’s mission and
priorities identified in the logic model
and the NCIPC Research Agenda?
Outline a conceptual research
framework, design, methods, and
analyses that are well integrated, and
appropriate to the aims of the center?
Propose research project(s) that address
an important research objective related
to youth interpersonal violence
prevention and disparities in the
defined community? Explain how this
research will lead to a better
understanding of factors influencing
youth violence prevention in the
defined community?
(ii) Articulate the significance of the
proposed research, and describe the
effect of these studies on the concepts
or methods that drive the youth
violence prevention field? Employ novel
concepts, approaches or methods in
youth violence prevention research?
Explain how the research challenges
existing paradigms or develops new
methodologies or technologies? Propose
research of sufficient originality,
novelty, and innovation to make it
highly relevant to the overall goals and
objectives of the national ACE Program?
Acknowledge potential problem areas
and consider alternative
interdisciplinary approaches? Offer
clear evidence of significant
interdisciplinary interactions in the
conception, design, and proposed
implementation of the research?
(iii) Document collaboration with the
community, providing clear evidence of
community participation in developing
and conducting the project?
Demonstrate community support and
liaison, and evidence of interaction
with, and participation of community
members and community leaders in the
development and conduct of the
research? Propose a design that
demonstrates sensitivity to cultural and
socioeconomic factors in the
community?
(iv) Demonstrate success in
conducting, evaluating, and publishing
previous community-based youth
violence prevention research in the past
five years? Demonstrate a reasonable
degree of community-based
participatory research, and being trained
and well-suited to carry out this work?

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Propose work appropriate to the
experience level of center researchers?
(v) Describe a scientific environment
conducive to the probability of success
of the research to be conducted?
Propose studies that take advantage of
unique features of the scientific
environment or employ useful
collaborative arrangements? Provide
evidence of adequate institutional and
community support?
(vi) Provide sufficient evidence
regarding the development and
implementation of effective
communication channels between
researchers and community members?
Address plans for useful and successful
practical dissemination of project
activities and findings within the
defined community?
3. Outreach and Education Core
(Total: 150 Points)
(a) Community Mobilization Plan (50
points). To what extent does the
applicant’s draft plan:
(i) Enhance the community’s capacity
to address the problem of youth
violence and improve the health of the
community, by preventing or reducing
youth violence, particularly among
those most affected?
(ii) Present clear goals, objectives and
activities that address the youth
violence problem in the defined
community? Address and take into
account community contextual factors
(i.e. socioeconomic and cultural context,
level of youth violence, public health
and youth violence prevention
infrastructure, history of community
participation and existing support for
the issue)?
(iii) Offer adequate evidence of center
experience in successfully developing,
conducting, evaluating, and publishing
on community mobilization activities in
the past five years? Delineate
community involvement in the
development of the CMP?
(iv) Address the development and
review of the plan (i.e. describe external
review and critique mechanisms)?
(b) Communications and
Dissemination (50 points). To what
extent does the applicant: (i) Address
the diversity or special needs of the
community or subgroups, (ii) describe
communications and dissemination
activities that are integrated into the
center’s goals and objectives, (iii)
anticipate how these activities will have
an effect on local policies, and other
potential outcomes, (iv) describe how
the proposed methods for the center’s
communication and dissemination
activities to help accomplish the
center’s goals and objectives, and (v)
describe an adequate infrastructure of
resources and personnel to support the

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center’s communication and
dissemination activities?
(c) Training, Technical Assistance
and Mentoring (50 points). To what
extent does the applicant: (i) Describe
and justify the center’s assets or needs
assessments for training, technical
assistance, or mentoring activities, (ii)
outline a suitable training, technical
assistance, and mentoring plan that
reflects the mission of the center and the
assets or needs assessment described
above, (iii) describe the opportunities
and quality of the career development
and mentoring plan for the junior
investigators in the center.
Protection of Human Subjects from
Research Risks: Does the applicant
adequately address the requirements of
Title 45 CFR part 46 for the protection
of human subjects? This will not be
scored; however, an application can be
disapproved if the research risks are
sufficiently serious and protection
against risks is so inadequate as to make
the entire application unacceptable.
Inclusion of Women, Minorities in
Research: Does the applicant adequately
address the CDC Policy requirements
regarding the inclusion of women,
ethnic, and racial groups in the
proposed research? (See Attachment 1,
AR–2 for more information). This
includes: (1) The proposed plan for the
inclusion of both sexes and racial and
ethnic minority populations for
appropriate representation; (2) the
proposed justification when
representation is limited or absent; (3) a
statement as to whether the design of
the study is adequate to measure
differences when warranted; and (4) a
statement as to whether the plans for
recruitment and outreach for study
participants include the process of
establishing partnerships with
community(ies) and recognition of
mutual benefits.
Inclusion of Children as Participants
in Research Involving Human Subjects.
The NIH maintains a policy that
children (i.e., individuals under the age
of 21) must be included in all human
subjects research, conducted or
supported by the NIH, unless there are
scientific and ethical reasons not to
include them. This policy applies to all
initial (Type 1) applications submitted
for receipt dates after October 1, 1998.
NCIPC has adopted this policy for this
announcement.
All investigators proposing research
involving human subjects should read
the ‘‘NIH Policy and Guidelines’’ on the
inclusion of children as participants in
research involving human subjects that
is available at: http://grants.nih.gov/
grants/funding/children/children.htm.

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Budget: The reasonableness of the
proposed budget and the requested
period of support in relation to the
proposed research.
V.2. Review and Selection Process
Applications will be reviewed by the
Procurement and Grants Office (PGO)
staff for completeness, and for
responsiveness by the National Center
for Injury Prevention and Control.
Incomplete applications and
applications that are non-responsive
will not advance through the review
process. Applicants will be notified that
their application did not meet
submission requirements.
Applications that are complete and
responsive to the announcement will be
evaluated for scientific and technical
merit by an appropriate peer review
group or charter study section convened
by the National Center for Injury
Prevention and Control in accordance
with the review criteria listed above. As
part of the initial merit review, all
applications may:
• Undergo a process in which only
those applications deemed to have the
highest scientific merit by the review
group, generally the top half of the
applications under review, will be
discussed and assigned a priority score.
• Receive a written critique.
• Receive, if deemed to have the
highest scientific merit, a second
programmatic level review by the
Science and Program Review
Subcommittee (SPRS) of the Advisory
Committee for Injury Prevention and
Control (ACIPC).
Applications which are complete and
responsive may be subjected to a
preliminary evaluation (streamline
review) by an external peer review
committee, the National Center for
Injury Prevention and Control Initial
Review Group (IRG), to determine if the
application is of sufficient technical and
scientific merit to warrant further
review by the IRG. CDC will withdraw
from further consideration applications
judged to be noncompetitive and
promptly notify the principal
investigator/program director and the
official signing for the applicant
organization. Those applications judged
to be competitive shall be further
evaluated by a dual review process.
All awards will be determined by the
Director of the NCIPC based on priority
scores assigned to applications by the
primary review committee IRG,
recommendations by the secondary
review committee of the Science and
Program Review Subcommittee of the
Advisory Committee for Injury
Prevention and Control (ACIPC),

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consultation with NCIPC senior staff,
and the availability of funds.
The primary review will be a peer
review conducted by the IRG. All
applications will be reviewed for
scientific merit in accordance with the
review criteria listed above.
Applications will be assigned a score
based on a scoring system of 100–500
points, in which the strongest
applications will receive a higher point
score, and the weakest applications a
lower point score.
The Science and Program Review
Subcommittee (SPRS) of NCIPC’s
Advisory Committee for Injury
Prevention and Control (ACIPC) will
conduct the secondary review. The
ACIPC Federal agency experts will be
invited to attend the secondary review,
and will receive modified briefing books
(i.e., abstracts, strengths and weaknesses
from summary statements, and project
officer’s briefing materials). ACIPC
Federal agency experts will be
encouraged to participate in
deliberations when applications address
overlapping areas of research interest, so
that unwarranted duplication in
federally funded research can be
avoided and special subject area
expertise can be shared. The NCIPC
Division Associate Director for Science
(ADS) or their designees will attend the
secondary review in a similar capacity
as the ACIPC Federal agency experts to
assure that research priorities of the
announcement are understood and to
provide background regarding current
research activities. Only SPRS members
will vote on funding recommendations,
and their recommendations will be
carried to the entire ACIPC for voting by
the ACIPC members in closed session. If
any further review is needed by the
ACIPC, regarding the recommendations
of the SPRS, the factors considered
would be the same as those considered
by the SPRS.
The secondary review committee’s
responsibility is to develop funding
recommendations for the NCIPC
Director based on the results of the
primary review, the relevance and
balance of proposed research relative to
the NCIPC programs and priorities, and
to assure that unwarranted duplication
of federally-funded research does not
occur. The secondary review committee
has the latitude to recommend to the
NCIPC Director, to reach over betterranked proposals in order to assure
maximal impact and balance of
proposed research. The factors to be
considered will include:
a. The results of the primary review
including the application’s priority
score as the primary factor in the
selection process.

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b. The relevance and balance of
proposed research relative to the NCIPC
programs and priorities.
c. The significance of the proposed
activities in relation to the priorities and
objectives stated in ‘‘Healthy People
2010,’’ the Institute of Medicine report,
‘‘Reducing the Burden of Injury,’’ and
the ‘‘CDC Injury Research Agenda.’’
d. Budgetary considerations.
Award Criteria: Criteria that will be
used to make award decisions during
the programmatic review include:
• Merit (as determined by peer review)
• Availability of funds
• Geographic diversity
• Consistency with research priorities
in CDC’s Injury Research Agenda
V.3. Anticipated Announcement and
Award Dates
September 1, 2005.
VI. Award Administration Information
VI.1. Award Notices
Successful applicants will receive a
Notice of Grant Award (NGA) from the
CDC Procurement and Grants Office.
The NGA shall be the only binding,
authorizing document between the
recipient and CDC. The NGA will be
signed by an authorized Grants
Management Officer, and mailed to the
recipient fiscal officer identified in the
application.
Unsuccessful applicants will receive
notification of the results of the
application review by mail.
VI.2. Administrative and National
Policy Requirements 45 CFR Part 74 and
Part 92
For more information on the Code of
Federal Regulations, see the National
Archives and Records Administration at
the following Internet address: http://
www.access.gpo.gov/nara/cfr/cfr-tablesearch.html.
The following additional
requirements apply to this project:
• AR–1 Human Subjects
Requirements.
• AR–2 Requirements for Inclusion of
Women and Racial and Ethnic
Minorities in Research.
• AR–9 Paperwork Reduction Act
Requirements. Projects that involve
the collection of information from ten
or more persons and that are funded
by cooperative agreements will be
subject to review and approval by the
Office of Management and Budget
(OMB).
• AR–10 Smoke-Free Workplace
Requirements.
• AR–11 Healthy People 2010.
• AR–12 Lobbying Restrictions.

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• AR–13 Prohibition on Use of CDC
Funds for Certain Gun Control
Activities.
• AR–21 Small, Minority, WomenOwned Businesses.
• AR–22 Research Integrity.
• AR–23 States and Faith-Based
Organizations.
• AR–24 Health Insurance Portability
and Accountability Act Requirements.
Additional information on AR–1
through AR–24 can be found on the
CDC Web site at the following Internet
address: http://www.cdc.gov/od/pgo/
funding/ARs.htm.
• AR–25 Release and Sharing of Data.
Starting with the December 1, 2004
receipt date, all ‘‘Requests for
Applications (RFA)/Program
Announcements (PA)’’ soliciting
proposals for individual research
projects of $500,000 or more in total
(direct and indirect) costs per year
require the applicant to include a plan
describing how the final research data
will be shared/released or explain why
data sharing is not possible. Details on
data sharing and release, including
information on the timeliness of the
data and the name of the project data
steward, should be included in a brief
paragraph immediately following the
Research Plan Section of the PHS 398
form. References to data sharing and
release may also be appropriate in other
sections of the application (e.g.
background and significance, or human
subjects requirements). The content of
the data sharing and release plan will
vary, depending on the data being
collected and how the investigator is
planning to share the data. The data
sharing and release plan will not count
towards the application page limit and
will not factor into the determining
scientific merit or the priority scoring.
Investigators should seek guidance from
their institutions on issues related to
institutional policies, and local IRB
rules, as well as local, state and federal
laws and regulations, including the
Privacy Rule.

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Further detail on the requirements for
addressing data sharing in applications
for NCIPC funding may be obtained by
contacting NCIPC program staff or by
visiting the NCIPC Internet Web site at:
http://www.cdc.gov/ncipc/osp/
sharing_policy.htm.
VI.3. Reporting
You must provide the CDC with
original, plus two hard copies of the
following reports:
1. Interim progress report (PHS 2590,
OMB Number 0925–0001, rev. 5/2001)
no less than 90 days before the end of
the budget period. The progress report
will serve as your non-competing
continuation application, and must
contain the following elements:
a. Current Budget Period Activities
Objectives.
b. Current Budget Period Financial
Progress.
c. New Budget Period Program
Proposed Activity Objectives.
d. Detailed Line-Item Budget and
Justification.
e. Measures of Effectiveness.
f. Additional Requested Information.
2. Financial status report, no more
than 90 days after the end of the budget
period.
3. Final financial status and final
performance reports, no more than 90
days after the end of the project period.
4. Additional requested information:
The applicant will be responsible for
submitting information on program
performance. This will include, but is
not limited to the following: providing
information on all projects (i.e., core
projects, special interest projects, and
other funded projects) and products
(i.e., publications, presentations,
surveys, etc.); providing semi-annual
updates on information requested by the
program and provided in the
application; and collaborating with the
national ACE Program on the continued
development and improvement of a
reporting system.
These reports must be mailed to the
Grants Management Specialist listed in

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the ‘‘Agency Contract’’ section of this
announcement.
VII. Agency Contacts
We encourage inquiries concerning
this announcement. For general
questions about this announcement,
contact: Technical Information
Management Section, CDC Procurement
and Grants Office, 2920 Brandywine
Road, Atlanta, GA 30341–4146,
telephone: (770) 488–2700.
For questions about scientific/
research program technical issues
contact: Thomas Vogelsonger, National
Center for Injury Prevention and
Control, Centers for Disease Control and
Prevention, 4770 Buford Highway, NE.
MS K–02, Atlanta, GA 30341, telephone:
(770) 488–4823, FAX: (770) 488–1662,
e-mail: [email protected].
For questions about peer review
issues, contact: Gwen Cattledge, Ph.D.,
Centers for Disease Control and
Prevention, National Center for Injury
Prevention and Control, 4770 Buford
Hwy, NE., Mailstop K–02, Atlanta, GA
30341, telephone: 770–488–1430, email: [email protected].
For financial, grants management, or
budget assistance, contact: James
Masone, Contracts Specialist, CDC
Procurement and Grants Office, 2920
Brandywine Road, Atlanta, GA 30341–
4146, telephone: 770–488–2736, FAX:
770–488–2671, e-mail: [email protected].
VIII. Other Information
This and other CDC funding
opportunity announcements can be
found on the CDC Web site, Internet
address: http://www.cdc.gov. Click on
‘‘Funding’’ then ‘‘Grants and
Cooperative Agreements.’’
To locate the following attachments/
appendices for this program
announcement go to CDC Web site.
Dated: November 10, 2004.
William P. Nichols,
Acting Director, Procurement and Grants
Office, Centers for Disease Control and
Prevention.

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Narrative Description of the Conceptual
Framework for the National Academic
Centers of Excellence for Youth
Violence Prevention (ACE) Program
The conceptual framework for the
National Academic Centers of
Excellence for Youth Violence
Prevention (ACE) Program was
developed to describe the future
orientation of the program, its activities
and the outcomes it expects to achieve.
The national framework or logic model
was created through a participatory
process involving a diverse set of
national, state, and local stakeholders
and ACE grantees, and draws heavily
from the Centers for Disease Control
(CDC) Prevention Research Centers
(PRC) model. The elements of the
framework and its linkages are
consistent with the Congressional
language authorizing the establishment
of the program, and CDC research
policies.
This model serves as a planning
mechanism for center in guiding their
activities during the 5-year grant period.
The framework identifies the inputs,

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activities, outputs, and outcomes
common to all ACE’s and shows the
expected relationships among these
components. The diagram of the
framework summarizes how the
program is presumed to work. Although
the boxes of the framework are shown
in a linear fashion, the relationships
among them are expected to be
complex, interactive, and recursive over
time.
The national framework does not
imply that one size fits all. To reflect
uniqueness, each ACE should create
their own logic model by tailoring the
national framework or logic model to
the center’s specific activities and goals.
The national framework cannot show
the emphasis an individual ACE may
place on one type of activity over
another. The time required to achieve
different outputs may vary among ACEs
and depends on many factors, such as
the type of research conducted and
other activities undertaken, the amount
of resources devoted to activities such
as dissemination, and contextual
factors. Thus, the framework does not

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specify the time it may take to achieve
outputs or outcomes.
Diagram Note: The size of the boxes in the
diagram depends on the amount of text in
each box and does not denote the relative
importance of a specific element.

Inputs. The first column of the
conceptual framework, inputs, refers to
the assumptions underlying a program
and the infrastructure that must be in
place before a program can be
implemented. The four inputs the
framework captures are described
below.
Youth Prevention Priorities. Each ACE
is established to address youth
interpersonal violence prevention
priorities and enhance knowledge of
effective youth violence prevention in a
defined community. Community is
defined as a group of people who share
some or all of the following: geographic
boundaries; a sense of membership;
culture and language; common norms,
interests, or values; and common health
risks or conditions. [IOM 2002] [CDC/
ATSDR Principles of Community
Engagement] It refers to a population

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implement ACE projects and activities
and experience working with the
community, and expertise for evaluating
the implementation of the ACE’s
activities and to assess the ACE’s
outcomes and accomplishments. The
Centers are mandated to create an
infrastructure that facilitates initiatives
that involve researchers and
practitioners from varied disciplines,
and collaboration across university
centers. Finally, ACE capacity requires
communication and data systems that
enable and facilitate work, and
administrative capacity (e.g., financial
resources).
Relationships with Center Partners.
Each ACE is also expected to establish
and maintain center partnerships with
institutions such as state and local
Diagram Note: Two-way arrows connect
health, education, justice departments,
the youth violence prevention priorities and
other university partners, other ACEs,
box and the next three combined input
Injury Control Research Centers (ICRCs),
boxes.
Prevention Research Centers, national
ACE Community Committee. CDC will youth violence prevention
organizations, and CDC. Partnerships
require each ACE to form or work with
an existing ACE Community Committee. are intended to strengthen the ACE’s
surveillance, research, training,
This group comprises members of the
mentoring, community mobilizing and
ACE’s defined community and adult
dissemination activities in its identified
and youth representatives of agencies
and organizations that serve the Center’s community. Partners can collaborate
designated community. The Community with the ACE in designing and
conducting research and other ACE
Committee participates in the Center’s
projects and in disseminating research
organization, research, or other
activities. Committee members typically findings, which are expected to help
facilitate the translation of public health
represent an identified group or
research and related activities to
population and participate in the
practice and policy.
committee in order to provide the
perspective and knowledge of a
Diagram Note: A dotted box around these
designated population or group to the
three inputs indicates that the ACE, its
activities of the Center.
community, and its external partners are the
The inputs provided by an ACE
major stakeholders; they collaborate with
Community Committee to the ACE
each other to implement the ACE Program.
The inputs for Community Committee,
include guidance, advice on ACE
Infrastructure, and Relationships with
agendas and plans, expertise, contacts,
Partners also have two-way arrows touching
essential information about the
each other. A two-way arrow connects the
designated community as well as
combined boxes for these inputs with that for
intangible benefits. Some ACE’s may
the next input. One-way arrows also connect
wish to form additional advisory
the three boxes to the first two program
groups, as needed, such as a policy
activities.
board, a youth advisory board, or
Motivating Conditions for Developing
advisory committees for individual
and Maintaining Relationships. The
research projects. The decision to form
conceptual framework also recognizes
these additional groups depends on the
the conditions motivating the
needs of the ACE and the community.
ACE Infrastructure. Before conducting development and maintenance of
specific youth violence prevention
relationships with community partners
research, projects, and health promotion and others. These conditions may
activities, an ACE must have the
include trust and tangible or intangible
necessary internal infrastructure. This
benefits (such as access to expertise or
infrastructure includes the necessary
acceptance by a community) and
human resources capacity to recruit
sharing of resources gained from the
faculty with the necessary core
partnership. These conditions may
expertise, diversity and sensitivity. It
influence a partner’s willingness to form
also includes the necessary evaluation
a relationship with the ACE, the nature
expertise as well as faculty and staff
and strength of the relationship, and an
who have the requisite
ACE’s ability to sustain the relationship
multidisciplinary expertise to
over time.
that has a distinct identity. It can mean
residents of a geographic area, be that a
catchement area, neighborhood, school
district, city, county or region within a
county. It can be used with a modifier
or clause to describe a nongeographically based subgrouping such
as, but not exclusively: a community of
youth violence prevention workers, a
community of health professionals, or
an ethnic or language community. The
ACE program focuses its research
activities on the violence prevention
issues of high priority to the defined
community and that address state or
national youth violence prevention
priorities, and such gaps identified in
the Research Agenda of CDC’s National
Center for Injury Prevention and Control
and those stated in Healthy People 2010.

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Activities. The second and third
columns of the conceptual framework
capture the activities that include:
developing a research agenda;
developing a community mobilization
plan; conducting surveillance, research,
building capacity and implementing the
community mobilization plan. (Multisectoral and multi-disciplinary
collaboration and dissemination are
inputs and outputs, respectively.)
Research Agenda. An ACE is
encouraged to engage stakeholders
within its defined community in
developing an overall research plan,
identifying research priorities, selecting
research projects, recruiting research
participants, refining research methods,
developing interventions, conducting
research, and reporting and
disseminating research findings. ACE
Centers are charged with establishing a
five-year research agenda with tied to
one or more HHS objectives, Healthy
People 2010, NCIPC Research Agenda,
Guide to Community Prevention
Services and local youth violence
prevention research priorities.
Community Mobilization Plan. ACEs
are charged with the development and
implementation of a five-year
community mobilization or action plan
(in collaboration with the Community
Committee). Further, the development
of a Community Mobilization Plan
should be tied to the Research Agenda
with an identified relationship to one or
more youth violence prevention
priorities.
Diagram Note: A two-way arrow connects
the boxes for the development of the research
agenda and the development of the
community mobilization plan. One-way
arrows connect the boxes for the mobilization
plan and the research agenda to the next set
of activities. A two-way arrow connects the
research agenda and the mobilization plan as
these processes should inform one another.

Conduct Core Activities:
• Surveillance. This core area
includes the gathering, analysis and
interpretation of surveillance data to
enable the defined community with
whom the ACE is working to better
measure the problem of youth violence,
and accurately reflect trends in the
target community and the greater
community. All Surveillance activities
proposed should include an appropriate
translation and dissemination plan.
• Research. The research conducted
should be informed by local priorities,
the NCIPC Research Agenda, and
contribute to new methods of study,
understandings of, or ways to prevent
youth interpersonal violence. In
addition, ACEs may conduct research
funded by other federal agencies and by
state agencies, community-based

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organizations, and foundations. All
research is expected to be conducted
using sound research methods that
further the field of youth interpersonal
prevention research. All research
proposed under the ACE program
should include an appropriate
dissemination plan.
• Build Capacity. ACEs are also
charged with developing a five-year
plan to train, provide technical
assistance to, or mentor health
professionals, researchers, practitioners,
students, community members, and
others. These activities, which are
expected to be developed in
collaboration with the recipients, may
cover a range of topics, including youth
violence prevention best practices,
community building, research, and
evaluation as well as other needs
identified by ACE partners. ACEs may
also train and provide technical
assistance to community partners on
implementing specific prevention and
health promotion interventions,
including effective practices.
• Implement the Community
Mobilization Plan. ACE’s are expected
to form, nurture and advance
partnerships with the community
designed to implement evidence-based
strategies or promising programs.
Community implementation efforts can
include convening stakeholders—
including the most affected—helping to
organize across different sectors,
fostering strategic alliances, and
strengthening community bonds;
assessing community resources;
mapping community assets; and
enabling a fuller understanding of and
response to the nature and dynamics of
local violence.
Diagram Note: Two-way arrows connect
these four core activities to one another. Oneway arrows connect surveillance, research,
capacity building, and community
implementation to the three outputs
(intervention implementation,
communication and dissemination, and
training and technical assistance).

Outputs. The fourth column captures
outputs generated or produced as a
result of program activities. Through the
process of planning, carrying out public
health-related youth violence
prevention activities, and the promotion
of collective action, it is expected that
the professionals and community
residents will gain increased skills and
confidence (or a greater sense of
‘‘efficacy’’) enhancing its capacity for
prevention. Enhanced capacity includes
an improved ability on the part of
agencies and organizations to
implement and make well-reasoned
decisions about effective violence
prevention programs and services. It

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also includes enhanced academic
infrastructure in service-learning,
student practicum opportunities. This
capacity combines a community’s and a
university’s commitment, resources, and
skills to respond to public health needs
and priorities. Another aspect of
enhanced capacity is the development
of skilled ‘‘violence preventers.’’ This
term includes not only professionals—
both developing new skills for those
entering the field as young researchers/
practitioners and improving existing
skills of current violence prevention
workers—but also providing skills to
youth, parents, and volunteers.
Community stakeholders who
collaborate with the ACE’s in
implementing research projects and
who participate in ACE-sponsored
training and technical assistance
improve their skills as a result. The
selected measurable products, or
outputs, of these activities and
processes are described below.
Communication and Dissemination.
The communication and dissemination
of research and evaluation findings are
another type of output. These findings
are typically published in peer-reviewed
journals, books, and technical reports.
They also may be presented to various
audiences at professional conferences,
community meetings, or other settings,
and reported to the media. Findings
from research conducted with a
community should be shared with
community partners and with other
ACE’s.
Intervention Implementation. Many
ACEs develop, implement and test
violence prevention strategies, programs
and interventions in a community,
encouraging the implementation of
evidence-based strategies or promising
programs. A program may rely on a
curriculum, a manual, or a particular
prevention strategy or health promotion
tool, which is packaged and made
available to interested organizations or
individuals.
Training, Technical Assistance. ACE’s
training or technical assistance activities
can include an assessment of the skills
acquired, number of trainees and
recipients of technical assistance, the
number and duration of training or
technical assistance events, and the
satisfaction of participants with the
training or technical assistance they
received.
Diagram Note: Together, all the output
boxes connect to a combined set of two
outcome boxes through a one-way arrow.
These two outcomes connect to each other by
two-way arrows.

Outcomes. The last column of the
conceptual framework shows the

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outcomes, or the intended effects of
cumulative program activities over time.
Improved Practice and Policy. One
expected outcome of the ACE Centers’
activities is the uptake of interventions
and improved youth interpersonal
violence prevention practice and
policies. Surveillance, research,
capacity building, and community
implementation activities conducted by
the ACEs are expected to be translated
into community practice or policies
adopted by local and state health
departments, schools, other public
agencies (e.g., recreation departments,
housing authorities), and communitybased organizations. Over time, these
interventions and policies may be
disseminated beyond an ACE’s defined
community and receive widespread use.
Reduction of Risk Factors/Increase in
Protective Factors. Another expected
outcome of the ACE Centers’ activities
is the reduction of risk factors/increase
of protective factors in the community,
a result of the uptake of improved
violence prevention practice and
policies.
Expanded Resources and Recognition.
An ACE may be able to expand its
resources beyond the core funding,
research faculty, and initial
organizational and agency partnerships
that were formed when it first received
CDC funding. An ACE may also gain
recognition within a community and the
nation for expertise in a particular field
or area of youth interpersonal violence
prevention, and for its partnerships.
Diagram Note: One set of dotted lines
surrounds the boxes for the two outcomes. A
second set surrounds the two additional
boxes below it (expanded resources and
recognition). These groupings show the
potential relationships with other
components of the framework with which
they are logically connected or which they
are likely to influence or be influenced by.
The outcomes flow back through motivating
conditions and up the input column. They
also connect to youth violence prevention
agendas and down the input column. A oneway feedback arrow also extends from the
outcomes back to the inputs of youth
violence prevention priorities and motivating
conditions for developing and maintaining
relationships.

Contextual Conditions. The box
across the bottom of the conceptual
framework is for contextual conditions,
which are socioeconomic, political, and
cultural factors external to the ACE
Program that may not be within its
control but which may influence the
implementation of activities and
achievement of outcomes. Note that
these conditions may relate to all
components of the framework.
Evaluation. Evaluation is a part of the
ACE Program (noted at the top of the

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framework) that extends across all the
inputs, activities, outputs, and
outcomes, except for the ultimate
outcome. The arrow to each column
signifies that the ACE Program will
evaluate aspects of each component,
guided by performance monitoring and
evaluation questions. Many factors can
contribute to the final outcome, and
empirical data demonstrating a causal
link between proposed program
activities and improvements in
community health are lacking.
Therefore, the ACE Program will not
evaluate the ACEs’ effect on violenceinduced death, disability and injury
among adolescents, but will evaluate
program effect on improved practice
and policy, and reduction of risk
factors/increase in protective factors.
The ACE Program evaluation will
collect data that may include
information about how inputs are being
used to shape the ACE Program, which
activities are undertaken by the
collective program, the quality of the
activities, and the specific outcomes the
program is accomplishing. CDC, ACEs,
and other stakeholders can use
evaluation findings for many purposes,
including modifying program activities
or enhancing and strengthening
relationships with community partners.
Evaluation findings also provide
information that can be shared with
external stakeholders, can help
document the program’s value, and may
provide justification for continuing or
increasing program funding.
Appendix 2.—List of Indicators for the
National Academic Center of
Excellence on Youth Violence
Prevention Program
1. Evidence of ACE Community
Committee participation in the
determination of ACE violence
prevention priorities.
2. Level of ACE Community
Committee members satisfaction with
participation.
3. Evidence of establishment of
partnerships and maintenance of
partnerships.
4. Establishment of a Community
Mobilization Plan.
5. Establishment of a Research
Agenda.
6. Evidence of community
improvements in the ability to monitor
and describe youth violence.
7. Extent to which the research
portfolio is contributing to new methods
of study, understandings of, or ways to
prevent youth violence.
8. Evidence that the ACE Center is
mobilizing the community to implement
evidence-based strategies or promising
programs.

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9. Evidence of a communication and
dissemination plan, developed with
input from key partners.
10. Evidence of producing and
disseminating research findings through
peer-reviewed publications, and
educational or technical materials.
11. Evidence of a plan for training
researchers, practitioners and
community members.
12. Extent to which center activities
and evidence-based strategies have been
translated into the outcomes listed.
13. Extent to which researchers,
practitioners, and community members
have been trained, mentored, or
provided technical assistance in youth
violence prevention.
14. Evidence of new grants, contracts
or other resources awarded to the ACE
Center or its partners.
Appendix 3.—Glossary of Terms
Youth Interpersonal Violence
Youth interpersonal violence is
defined as: The intentional use of
physical force or power, threatened or
actual, exerted by or against children,
adolescents or young adults, ages 10–24,
which results in or has a high likelihood
of resulting in injury, death,
psychological harm, maldevelopment or
deprivation. Youth interpersonal
violence encompasses peer and
community violence between
individuals or groups who may or may
not know each other. This form of
violence frequently takes place outside
the home, in the streets, or in
institutional settings, such as schools,
workplaces, and prisons. Youth
violence also encompasses violence that
occurs between youth and family
members and other intimate relations.
The nature of violence can be physical,
sexual, and psychological. (Adapted
from WHO Report on Violence and
Health, 2002). [Adapted from WHO
Report on Violence and Health. To
access the Report go to: http://
www.who.int/
violence_injury_prevention/violence/
world_report/en/ ].
Community
Community is defined as a group of
people who share some or all of the
following: geographic boundaries; a
sense of membership; culture and
language; common norms, interests, or
values; and common health risks or
conditions. [IOM 2002] [CDC/ATSDR
Principles of Community
Engagement].—It refers to a population
that has a distinct identity. It can mean
residents of a geographic area, such as
a catchment area, neighborhood, school
district, city, county or region within a

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county. It can be used with a modifier
or clause to describe a nongeographically based sub-grouping such
as, but not exclusively: A community of
youth violence prevention workers, a
community of health professionals, or
an ethnic or language community.
Community Mobilization
Community mobilization is a process
through which action is stimulated by a
community itself or by others, that is
planned, carried out, and evaluated by
a community’s individuals, groups, and
organizations on a participatory and
sustained basis to reduce or prevent
youth violence, and improves health.
[Save the Children/Health
Communication Partnership]
Community Mobilization Plan (CMP)
The plan is a general description of
how you and your partners intend work
with a particular community to mobilize
around youth violence prevention. A
mobilization plan defines the overall
goals and objectives and identifies a
process that will help interested
communities achieve them, not to
determine specific community actions
or activities. The two overriding goals of
community mobilization are to: 1.
Enhance the community’s capacity to
address the problem of youth violence;
2. Prevent or reduce youth violence,
thereby improving the health of the
community.
The goal of a community mobilization
plan must be related to local youth
violence prevention priorities. Where
communities perceive a pressing youth
violence prevention need, communities
themselves may define the goal.
Alternatively, ACEs and their
stakeholders may identify a goal based
on an analysis of community health
indicators (e.g., frequency and severity
of specific health problems and
feasibility to address them). [Health
Communication Partnership]
Community Participation
The active involvement of the
members of a community in the
planning, creation, operation,
evaluation, dissemination and oversight
of an initiative or project.
Community Committee
A group of individuals that represent
groups and organizations within the
Center’s designated community. The
Community Committee participates in
the Center’s organization, research, or
other activities. Committee members
typically represent an identified group
or population and participate in the
committee in order to provide the
perspective and knowledge of a

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designated population or group to the
activities of the Center.
CDC will require each ACE to form an
ACE Community Committee. This group
should comprise members of the ACE’s
defined community and adult and youth
representatives of agencies and
organizations serving that community.
The inputs provided by an ACE
Community Committee to the ACE
include guidance, advice on ACE
agendas and plans, expertise, contacts,
essential information about the
designated community as well as
intangible benefits. Some ACE’s may
wish to form additional advisory
groups, as needed, such as a policy
board, a youth advisory board, or
advisory committees for individual
research projects. The decision to form
these additional groups depends on the
needs of the ACE and the community.
Center Partnerships
Each ACE is also expected to establish
and maintain center partnerships with
institutions such as state and local
health, education justice departments,
other university partners, other ACEs,
Injury Control Research Centers (ICRCs),
Prevention Research Centers, national
youth violence prevention
organizations, and CDC. Partnerships
are intended to make the ACE’s
surveillance, research, training and
mentoring, community mobilizing and
dissemination activities relevant to its
identified community. Partners can
collaborate with the ACE in designing
and conducting research and other ACE
projects and in disseminating research
findings, which are expected to help
facilitate the translation of public health
research and related activities to
practice and policy.
Community-Based Participatory
Research (CBPR)
Scientific inquiry conducted in
communities in which community
members, persons affected by condition
or issue under study and other key
stakeholders in the community’s health
have the opportunity to be full
participants in each phase of the work
(from conception—design—conduct—
analysis—interpretation—conclusions—
communication of results).
Definition Developed by Inter Agency
Working Group for CBPR, Convened by
NIEHS, NIH, August 2, 2002
According to the CARE–CDC Health
Initiative, A Model for Global
Participatory Research, in communitybased participatory research, the
definition of scientific rigor is
broadened to encompass community
participation in decisionmaking at every

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phase of the research process: defining
the problem, setting goals, selecting
methods, interpreting data, and
recommending policy. Essential to this
philosophical construct is the assurance
of quality decision making throughout
the research process. In the document
Building Community Partnerships in
Research, participatory research is
described as the gold standard toward
which all federally funded research
should aspire. (5)(p7). [Building
Community Partnerships in Research:
Recommendations and Strategies.
Executive Summary. Washington, DC:
U.S. Dept of Health and Human
Services; April 7, 1998.]
[FR Doc. 04–25667 Filed 11–19–04; 8:45 am]
BILLING CODE 4163–18–P

DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Food and Drug Administration
[Docket No. 2004D–0494]

Guidance for Industry on Changes to
an Approved New Drug Application or
Abbreviated New Drug Application;
Specifications—Use of Enforcement
Discretion for Compendial Changes
Food and Drug Administration.
Notice.

AGENCY:
ACTION:

SUMMARY: The Food and Drug
Administration (FDA) is announcing the
availability of a guidance for industry
entitled ‘‘Changes to an Approved NDA
or ANDA; Specifications—Use of
Enforcement Discretion for Compendial
Changes.’’ This guidance informs new
drug application (NDA) and abbreviated
new drug application (ANDA) holders
of FDA’s plan to use enforcement
discretion with regard to the regulation
on changes to an approved application.
This regulation describes the filing
requirement that a relaxation of
acceptance criteria or deletion of a test
to comply with an official compendium
must be reported in a changes-beingeffected-in-30-days supplement (CBE–
30). FDA does not intend to take
enforcement action if manufacturers
continue to submit such changes in
their annual reports. The use of
enforcement discretion will give the
agency time to clarify that some of these
types of postapproval changes can be
submitted in an annual report, rather
than in a CBE–30. The agency intends
to clarify this issue in an upcoming
revision to a guidance for industry.
DATES: Submit written or electronic
comments on agency guidances at any
time.

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ADDRESSES: Submit written requests for
single copies of this guidance to the
Division of Drug Information (HFD–
240), Center for Drug Evaluation and
Research, Food and Drug
Administration, 5600 Fishers Lane,
Rockville, MD 20857. Send one selfaddressed adhesive label to assist that
office in processing your requests.
Submit written comments on the
guidance to the Division of Dockets
Management (HFA–305), Food and Drug
Administration, 5630 Fishers Lane, rm.
1061, Rockville, MD 20852. Submit
electronic comments to http://
www.fda.gov/dockets/ecomments.
Requests and comments should be
identified with the docket number
found in brackets in the heading of this
document. See the SUPPLEMENTARY
INFORMATION section for electronic
access to the guidance document.
FOR FURTHER INFORMATION CONTACT:
David J. Cummings, Center for Drug
Evaluation and Research (HFD–357),
Food and Drug Administration, 5600
Fishers Lane, Rockville, MD 20857,
301–443–5187.
SUPPLEMENTARY INFORMATION:

I. Background
In the Federal Register of April 8,
2004 (69 FR 18728), FDA published a
final rule entitled ‘‘Supplements and
Other Changes to an Approved
Application.’’ In the same issue of the
Federal Register (69 FR 18768), FDA
announced the availability of the
guidance for industry entitled ‘‘Changes
to an Approved NDA or ANDA’’ (the
changes guidance). Under
§ 314.70(c)(2)(iii) (21 CFR
314.70(c)(2)(iii)) of the final rule, the
relaxation of an acceptance criterion or
deletion of a test to comply with an
official compendium that is consistent
with FDA statutory and regulatory
requirements must be submitted as a
CBE–30 (see section VIII.C.1.e of the
changes guidance).
FDA is issuing this guidance to
explain that it is using enforcement
discretion with regard to
§ 314.70(c)(2)(iii) to address concerns
raised by stakeholders. FDA plans to
clarify that some of these types of
changes can be submitted in an annual
report, instead of a CBE–30 supplement,
in a revision of the guidance for
industry entitled ‘‘Changes to an
Approved NDA or ANDA; Questions
and Answers.’’
This guidance contains information
collection provisions that are subject to
review by the Office of Management and
Budget (OMB) under the Paperwork
Reduction Act of 1995 (44 U.S.C. 3501–
3520). The collection of information in

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