Cover Memo_iCLIC

Date: September 13, 2010

TO: Office of Management and Budget (OMB)

Through: Seleda Perryman, DHHS Report Clearance Officer

Mikia Currie, NIH Program Analyst, Project Clearance Branch, OPERA

Vivian Horovitch-Kelley, NCI OMB Project Clearance Liaison, OMAA

FROM: Arthur Schatzkin, Division of Cancer Epidemiology and Genetics

National Cancer Institute

SUBJECT: The NIH-American Association for Retired Persons (AARP) interactive Comprehensive Lifestyle Interview by Computer Study (iCLIC) (NCI)

(OMB #0925-0594; expiration: 12/31/2010)

This is a request for OMB to approve the extension of “The NIH-American Association for Retired Persons (AARP) interactive Comprehensive Lifestyle Interview by Computer Study (iCLIC) (NCI),” for 3 years.

The Nutritional Epidemiology Branch of the Division of Cancer Epidemiology and Genetics of the National Cancer Institute has planned this study to evaluate the feasibility of using these three computerized questionnaires as well as the Diet and Health Questionnaire (DHQ), a well-established food frequency questionnaire in a population of early-to-late-middle-aged men and women. Participants will be asked to complete computerized questionnaires over a 90 day period, with some questionnaires in a series being completed twice. This evaluation study comprises the necessary performance and feasibility tests for the new computerized questionnaires, which will provide an opportunity to assess the possibility of administering computerized questionnaires in future large prospective cohort studies. The computerized questionnaires will support the ongoing examination between cancer and other health outcomes with nutritional, physical activity, and lifestyle exposures.

Due to the very low response rate and the extended time it took for respondents to answer the questionnaires, additional time is being requested with this submission. In particular, this submission encompasses the previous full submission, approved by OMB, in 2008 and two subsequent change requests, approved by OMB in April, 2009 and January, 2010. The additional time is in order to more fully evaluate to goals of this feasibility study using invitations by email only.

The computerized questionnaires adhere to The Public Health Service Act, Section 412 (42 USC 285a-1) and Section 413 (42 USC 285a-2), which authorizes the Division of Cancer Epidemiology and Genetics of the National Cancer Institute (NCI) to establish and support programs for the detection, diagnosis, prevention and treatment of cancer; and to collect, identify, analyze and disseminate information on cancer research, diagnosis, prevention and treatment.