Published 60 Day Federal Register Notice (FRN)

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Federal Register / Vol. 88, No. 79 / Tuesday, April 25, 2023 / Notices

pressure and mutational rate, leading to
the well-known seasonal variation of
influenza virus. In contrast, the
nucleocapsid viral protein (NP), located
in the interior of the virus, is more
conserved and an ideal antibody target;
however, NP is inaccessible to
extracellular antibodies produced in
response to infection. To circumvent the
challenge of targeting NP, scientists at
NIAID have developed an antibody
genetically fused with a cell penetrating
peptide (CPP-mAb) that targets NP
within infected cells to effectively
inhibit viral replication. By targeting NP
rather than the surface glycoproteins,
this CPP-mAb can treat more influenza
variants, potentially across flu seasons,
and is an improvement upon current
influenza treatments.
This technology is available for
licensing for commercial development
in accordance with 35 U.S.C. 209 and 37
CFR part 404, as well as for further
development and evaluation under a
research collaboration.
Potential Commercial Applications:
• Clinical Treatment: CPP-mAbs
against influenza NP may be a reliable
and effective method to treat patients
infected with varying subtypes of
influenza, by targeting a functionally
conserved protein.
• CPP-mAbs could be a viable
alternative to the treatment of influenza
when other treatments are ineffective,
potentially lowering the mortality and
morbidity rates in populations
susceptible to influenza infection.
Competitive Advantages:
• Current vaccines remain effective
for a short time period, due to the everchanging nature of the viral surface
glycoproteins. CPP-mAbs could remain
effective for a longer time period by
targeting the interior NP of influenza,
which is more conserved across
influenza subtypes.
• Other attempts to produce vaccines
against conserved portions of the
surface viral glycoproteins have failed to
produce a robust and reliable vaccine.
CPP-mAbs could be a more reliable
therapeutic agent compared to
alternatives, potentially effective across
flu seasons.
• In vivo efficacy: CPP-mAbs against
NP increase survivorship in mice
infected with mouse Influenza A virus,
demonstrating therapeutic protection.
Development Stage:
• Pre-Clinical.
Inventors: Jonathon Yewdell, MD,
Ph.D. and Ivan Kosik, Ph.D., both from
NIAID.
Publications: Publication pending.
Intellectual Property: HHS Reference
No. E–193–2021; US Provisional

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Application No. 63/365,841, filed on
June 3rd, 2022.
Licensing Contact: To license this
technology, please contact Benjamin
Hurley at 240–669–5092 or
[email protected], and reference
E–193–2021.
Collaborative Research Opportunity:
The National Institute of Allergy and
Infectious Diseases is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize this invention. For
collaboration opportunities, please
contact Benjamin Hurley; 240–669–
5092, [email protected].
Dated: April 19, 2023.
Surekha Vathyam,
Deputy Director, Technology Transfer and
Intellectual Property Office, National Institute
of Allergy and Infectious Diseases.
[FR Doc. 2023–08642 Filed 4–24–23; 8:45 am]
BILLING CODE 4140–01–P

DEPARTMENT OF HOMELAND
SECURITY
Federal Emergency Management
Agency
[Docket ID: FEMA–2023–0011; OMB No.
1660–0015]

Agency Information Collection
Activities: Proposed Collection;
Comment Request; Revisions to
National Flood Insurance Program
Maps: Application Forms and
Instructions for (C)LOMAs and
(C)LOMR–Fs
Federal Emergency
Management Agency, Department of
Homeland Security.
ACTION: 60-Day notice of revision and
request for comments.
AGENCY:

The Federal Emergency
Management Agency (FEMA), as part of
its continuing effort to reduce
paperwork and respondent burden,
invites the general public to take this
opportunity to comment on an
extension, with change of a currently
approved information collection. In
accordance with the Paperwork
Reduction Act of 1995, this notice seeks
comments concerning information
required by FEMA to amend or revise
National Flood Insurance Program
(NFIP) maps to remove certain property
from the one-percent annual chance
floodplain.
DATES: Comments must be submitted on
or before June 26, 2023.
ADDRESSES: To avoid duplicate
submissions to the docket, please
SUMMARY:

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submit comments at
www.regulations.gov under Docket ID
FEMA–2023–0011. Follow the
instructions for submitting comments.
All submissions received must
include the agency name and Docket ID.
Regardless of the method used for
submitting comments or material, all
submissions will be posted, without
change, to the Federal eRulemaking
Portal at http://www.regulations.gov,
and will include any personal
information you provide. Therefore,
submitting this information makes it
public. You may wish to read the
Privacy and Security Notice that is
available via a link on the homepage of
www.regulations.gov.
FOR FURTHER INFORMATION CONTACT:

Bryan Anderson, FEMA, Federal
Insurance & Mitigation Administration,
at (202) 577–2397 or Bryanb.Anderson@
fema.dhs.gov. You may contact the
Information Management Division for
copies of the proposed collection of
information at email address: FEMAInformation-Collections-Management@
fema.dhs.gov.
The
National Flood Insurance Program
(NFIP) is authorized by the National
Flood Insurance Act of 1968, as
amended, 42 U.S.C. 4001 et seq. The
Federal Emergency Management Agency
(FEMA) administers the NFIP and
maintains the maps that depict flood
hazard information. The land area
covered by the floodwaters of the base
flood is the Special Flood Hazard Area
(SFHA) on NFIP maps. The SFHA is the
area where the NFIP’s floodplain
management regulations must be
enforced and the area where the
mandatory purchase of flood insurance
applies. If a SFHA has been determined
to exist for property and the owner or
lessee of the property believes his/her
property has been incorrectly included
in a SFHA, information can be provided
to support removal of the SFHA
designation. NFIP regulations, at 44 CFR
parts 65 and 70, outline the data that
must be submitted by an owner or lessee
of property who believes their property
has been incorrectly included in a
SFHA. In order to remove an area from
a SFHA, the owner or lessee of the
property must submit scientific or
technical data demonstrating that the
area is ‘‘reasonably safe from flooding’’
and not in the SFHA.
This information collection is set to
expire on July 31, 2023. FEMA is
requesting a revision to the currently
approved information collection.

SUPPLEMENTARY INFORMATION:

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Federal Register / Vol. 88, No. 79 / Tuesday, April 25, 2023 / Notices
Collection of Information
Title: Revisions to National Flood
Insurance Program Maps: Application
Forms and Instructions for (C)LOMAs
and (C)LOMR–Fs.
Type of Information Collection:
Revision of a currently approved
information collection.
OMB Number: 1660–0015.
FEMA Forms: FEMA Form FF–206–
FY–23–104 (formerly 086–0–22) and
FEMA Form FF–206–FY–23–104–A
(formerly 086–0–22A (Spanish)),
Application Form for Single Residential
Lot or Structure Amendments to
National Flood Insurance Program
Maps; FEMA Form FF–206–FY–23–105
(formerly 086–0–26), Property
Information Form; FEMA Form FF–206–
FY–23–106 (formerly 086–0–26A),
Elevation Form; and FEMA Form FF–
206–FY–23–107 (formerly 086–0–26B),
Community Acknowledgment Form.
Abstract: FEMA collects scientific and
technical data submissions to determine
whether a specific property is located
within or outside of a SFHA. If the
property is determined not to be within
a SFHA, FEMA provides a written
determination and the appropriate map
is modified by a Letter of Map
Amendment (LOMA) or a Letter of Map
Revision—Based on Fill (LOMR–F),
making it possible for the lending
institution to waive the flood insurance
requirement.
Affected Public: Individuals or
households; Business or other for-profit
institutions; State, Local or Tribal
government.
Estimated Number of Respondents:
67,701.
Estimated Number of Responses:
67,701.
Estimated Total Annual Burden
Hours: 71,234.
Estimated Total Annual Respondent
Cost: $3,474,941.
Estimated Respondents’ Operation
and Maintenance Costs: $12,215,500.
Estimated Respondents’ Capital and
Start-Up Costs: $0.
Estimated Total Annual Cost to the
Federal Government: $112,712.

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Comments
Comments may be submitted as
indicated in the ADDRESSES caption
above. Comments are solicited to (a)
evaluate whether the proposed data
collection is necessary for the proper
performance of the Agency, including
whether the information shall have
practical utility; (b) evaluate the
accuracy of the Agency’s estimate of the
burden of the proposed collection of
information, including the validity of
the methodology and assumptions used;

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(c) enhance the quality, utility, and
clarity of the information to be
collected; and (d) minimize the burden
of the collection of information on those
who are to respond, including through
the use of appropriate automated,
electronic, mechanical, or other
technological collection techniques or
other forms of information technology,
e.g., permitting electronic submission of
responses.
Millicent Brown Wilson,
Records Management Branch Chief, Office
of the Chief Administrative Officer, Mission
Support, Federal Emergency Management
Agency, Department of Homeland Security.
[FR Doc. 2023–08703 Filed 4–24–23; 8:45 am]
BILLING CODE 9110–12–P

DEPARTMENT OF HOMELAND
SECURITY
U.S. Citizenship and Immigration
Services
[OMB Control No. 1615–0029]

Agency Information Collection
Activities; Revision of a Currently
Approved Collection: Application for
Waiver of Grounds of Inadmissibility
U.S. Citizenship and
Immigration Services, Department of
Homeland Security.
ACTION: 30-Day notice.
AGENCY:

The Department of Homeland
Security (DHS), U.S. Citizenship and
Immigration Services (USCIS) will be
submitting the following information
collection request to the Office of
Management and Budget (OMB) for
review and clearance in accordance
with the Paperwork Reduction Act of
1995. The purpose of this notice is to
allow an additional 30 days for public
comments.
DATES: Comments are encouraged and
will be accepted until May 25, 2023.
ADDRESSES: Written comments and/or
suggestions regarding the item(s)
contained in this notice, especially
regarding the estimated public burden
and associated response time, must be
submitted via the Federal eRulemaking
Portal website at http://
www.regulations.gov under e-Docket ID
number USCIS–2007–0042. All
submissions received must include the
OMB Control Number 1615–0029 in the
body of the letter, the agency name and
Docket ID USCIS–2007–0042.
FOR FURTHER INFORMATION CONTACT:
USCIS, Office of Policy and Strategy,
Regulatory Coordination Division,
Samantha Deshommes, Chief,
Telephone number (240) 721–3000
SUMMARY:

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(This is not a toll-free number;
comments are not accepted via
telephone message.). Please note contact
information provided here is solely for
questions regarding this notice. It is not
for individual case status inquiries.
Applicants seeking information about
the status of their individual cases can
check Case Status Online, available at
the USCIS website at http://
www.uscis.gov, or call the USCIS
Contact Center at (800) 375–5283; TTY
(800) 767–1833.
SUPPLEMENTARY INFORMATION:
Comments
The information collection notice was
previously published in the Federal
Register on December 29, 2022, at 87 FR
80194, allowing for a 60-day public
comment period. USCIS did receive 2
comments in connection with the 60day notice.
You may access the information
collection instrument with instructions,
or additional information by visiting the
Federal eRulemaking Portal site at:
http://www.regulations.gov and enter
USCIS–2007–0042 in the search box.
The comments submitted to USCIS via
this method are visible to the Office of
Management and Budget and comply
with the requirements of 5 CFR
1320.12(c). All submissions will be
posted, without change, to the Federal
eRulemaking Portal at http://
www.regulations.gov, and will include
any personal information you provide.
Therefore, submitting this information
makes it public. You may wish to
consider limiting the amount of
personal information that you provide
in any voluntary submission you make
to DHS. DHS may withhold information
provided in comments from public
viewing that it determines may impact
the privacy of an individual or is
offensive. For additional information,
please read the Privacy Act notice that
is available via the link in the footer of
http://www.regulations.gov.
Written comments and suggestions
from the public and affected agencies
should address one or more of the
following four points:
(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility;
(2) Evaluate the accuracy of the
agency’s estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and

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