Generic Clearance for the Research Domain Criteria (RDoC) Initiative (NIMH)

NIMH developed a research framework for new ways of studying mental disorders known as RDoC through a series of workshops (https://www.nimh.nih.gov/research-priorities/rdoc/development-of-the-rdoc-framework.shtml). The framework integrates many levels of information (from genomics to self-report) to better understand basic dimensions of functioning underlying the full range of human behavior from normal to abnormal. This effort resulted in the creation of a matrix of units of analysis (from molecules to self-report) for several domains (cognitive, positive valence, negative valence, social processes, arousal and regulatory systems)—all examined in a context emphasizing developmental trajectories and individual’s interactions with their environment. The RDoC matrix has become a framework for organizing our research efforts, with the aim to guide research that begins with disruptions in neurobiological and behavioral mechanisms, and then works across systems to clarify connections among such disruptions and clinical symptoms; it is a flexible entity that can be updated as new research emerges that could influence the understanding of psychopathology.

The latest form for Generic Clearance for the Research Domain Criteria (RDoC) Initiative (NIMH) expires 2021-07-31 and is listed under ICR 201804-0925-001.

RDoC Training Meeting Survey

Federal Enterprise Architecture: Health - Health Care Services

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