Pre Test

Experimental Study on the Public Display of Lists of Harmful and Potential Harmful Tobacco Constituents

HPHC_Prototype1Cigarette22

Pre Test

OMB: 0910-0736

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U.S. Food and Drug Administration

Logo Sheet 1298.01

Tobacco Product: Brand X Cigarette
All tobacco products contain chemicals.

KEY

The purpose of this list is to provide information about the chemicals in this tobacco product

Chemicals have been linked to:

that researchers have linked to health problems. Research is on going to find out which chemicals
in tobacco and tobacco smoke cause harm.

Cancer
Lung Disease

There may be other health problems and chemicals that have not been discovered yet.
Tobacco companies test their cigarettes for these chemicals and report the amounts to the FDA.

Heart and Blood Vessel Problems

Please note: There is no safe tobacco product. Based on what we currently know, you can not

Reproductive Problems

tell your chance of developing a health problem by the number of chemicals or the amount of a
chemical in a tobacco product.

Addiction

TOBACCO

per gram

SMOKE

TOBACCO

ND
F

Amount
per gram
Per Gram

n

Acetaldehyde

n

FP L A N TAcetamide

F

F

F

60 – 240 µg

per
cigarette

PLANT

amount per
gram of
tobacco

amount per
gram of
tobacco

&

Acetone

FOUND IN

SMOKE

n
n

Acrolein

Acrylamide

n

3 - 15 µg

Acrylonitrile

n

Aflatoxin B1

n

&

ND

FOUND IN

S 4-Aminobiphenyl
MOKE
amount per
cigarette

n

Where do these chemicals
come from?
per gram

n

1-Aminonaphthalene

n

ND

2-Aminonaphthalene

n

amount per
gram of
tobacco

per
cigarette

n

10 - 130 µg

Ammonia

F

F

Anabasine

F

F

o-Anisidine

n

40 - 120 ng

F

Arsenic

n

F

A-α-C (2-Amino-9H-pyrido[2,3-b]indole)

n

F

Benz[a]anthracene

n

F

Benz[j]aceanthrylene

n

Benzene

n

n

n
n

n

n
n

12 - 50 µg

F

F

Benzo[b]fluoranthene

n

n

F

Benzo[k]fluoranthene

n

n

F

Benzo[b]furan

n

8.5 – 17.6 ng

Benzo[a]pyrene

n

F

Benzo[c]phenanthrene

n

F

Beryllium

n

F

1,3-Butadiene

n

n

n

41 - 62 ng

F

Cadmium

n

n

n

F

F

Caffeic acid

n
n

Carbon monoxide

F

Catechol

n

F

Chlorinated dioxins/furans

n

F

F

Chromium

n

F

F

Chrysene

n

n

F

F

Cobalt

n

n

F

n
n

n

Coumarin (banned in food)

F
F

F

Cresols (o-, m-, and p-cresol)

n

F

ND

Crotonaldehyde

n

F

Cyclopenta[c,d]pyrene

n

F

Dibenz[a,h]anthracene

n

F

Dibenzo[a,e]pyrene

n

F

Dibenzo[a,h]pyrene

n

F

Dibenzo[a,i]pyrene

n

F

Dibenzo[a,l]pyrene

n

F

F

2,6-Dimethylaniline

n

F

F

Ethyl carbamate (urethane)

n

F

F

Ethylbenzene

n

FOUND IN

PLANT

amount per
gram of
tobacco

F

14 - 23 mg

FOUND IN

SMOKE

170 - 370 mg

F

per
cigarette

P L Afrom
NT
Many of these chemicals come
the tobacco leaf and the smoke.
The rest come from the filter, glue, ink,
paper and additives.

n

3 - 4 ng

SMOKE

TOBACCO

n

amount per
cigarette

F

FOUND IN

F

per gram

n

FOUND IN

SMOKE

F

TOBACCO

The information is not currently
available

Amount per
cigarette
Per Cigarette
CHEMICAL
770 - 864 µg

Not Detected

n

n

A machine is used to test for these chemicals. The amount of chemical that gets into the body may be
higher or lower depending on how a person uses the tobacco product. Companies may use different tests to
measure these chemicals. Results may vary.

mg= milligram
µg = microgram
ng = nanogram
pg= picogram

&

FOUND IN

SMOKE

amount per
cigarette

&

S

U.S. Food and Drug Administration

Logo Sheet 1298.01

TOBACCO

Tobacco Product: Brand X Cigarette
per gram

KEY
SMOKE

TOBACCO

Chemicals have been linked to:
Cancer

Amount
per gram
Per Gram

Amount per
cigarette
Per Cigarette
CHEMICAL

Lung Disease

Ethylene oxide

F
FOUND IN

S M OFK E

10.3 -25
P LµgA N TFormaldehyde
F

FOUND IN

tobacco

Furan

&

FOUND IN

SMOKE

amount per
cigarette

n

n

n

Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]
imidazole)

n

F

Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)

n

F

Hydrazine

n

&
F

Indeno[1,2,3-cd]pyrene

n

F

IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)

n

Isoprene

n

F

Lead

n

F

MeA-α-C (2-Amino-3-methyl)-9H-pyrido[2,3-b]indole)

n

F

F

Mercury

n

F

F

Methyl ethyl ketone

F

5-Methylchrysene

n

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

n

F

Reproductive Problems

n
n

S Hydrogen
M O K E cyanide

F

450 - 1000 µg

n

F

Naphthalene

n

n

F

F

Nickel

n

n

11.3 – 26.7 mg

0.1-3.0 mg

ND

F

Nitrobenzene

n

F

Nitromethane

n

F

2-Nitropropane

n

F

F

N-Nitrosodiethanolamine (NDELA)

n

F

F

N-Nitrosodiethylamine (NDEA)

n

F

F

N-Nitrosodimethylamine (NDMA)

n

F

F

N-Nitrosomethylethylamine

n

N-Nitrosomorpholine (NMOR)

n

per gram

n

F

F

N-Nitrosopiperidine (NPIP)

n

F

F

N-Nitrosopyrrolidine (NPYR)

n

F

N-Nitrososarcosine (NSAR)

n

F

Nornicotine

per
cigarette

FOUND IN

SMOKE

n

N-Nitrosonornicotine (NNN)

SMOKE

TOBACCO

Where do these chemicals
come from?

Nicotine

154 - 196 ng

TOBACCO

The information is not currently

per gram

n

0.9 – 6.9 µg

Not Detected

n
n

F

n

n

n

P L Afrom
NT
Many of these chemicals come
the tobacco leaf and the smoke.
The rest come from the filter, glue, ink,
paper and additives.
amount per
gram of
tobacco

per
cigarette

FOUND IN

PLANT

amount per
gram of
tobacco

mg= milligram
µg = microgram
ng = nanogram
pg= picogram

n
n

n

n

n

F

Phenol

F

PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]
pyridine)

n

F

F

Polonium-210

n

F

F

Propionaldehyde

F

F

Propylene oxide

n

F

F

Quinoline

n

F

F

Selenium

F

F

Styrene

n

F

F

2-Toluidine

n

F

ND

Toluene

F

Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)

n

F

Trp-P-2 (1-Methyl-3-amino-5H-pyrido[4,3-b]indole )

n

F

Uranium-235

n

n

F

Uranium-238

n

n

F

Vinyl acetate

n

n

F

Vinyl chloride

n

F

ND

available

110 - 133 ng

F

n

F

0.1 – 1.6 µg

F

Heart and Blood Vessel Problems

Addiction

FOUND IN

amount per
cigarette

n

n

F
per
cigarette

F
PLANT
amount per
F
gram of

amount per
gram of
tobacco

n

n
n

n

n

A machine is used to test for these chemicals. The amount of chemical that gets into the body may be
higher or lower depending on how a person uses the tobacco product. Companies may use different tests to
measure these chemicals. Results may vary.

&

FOUND IN

SMOKE

amount per
cigarette

&

S


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