Pre Test

Experimental Study on the Public Display of Lists of Harmful and Potential Harmful Tobacco Constituents

HPHC_Prototype2Cigarette22

Pre Test

OMB: 0910-0736

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U.S. Food and Drug Administration

Logo Sheet 1298.01

Tobacco Product: Brand X Cigarette
All tobacco products contain chemicals.

KEY

The purpose of this list is to provide information about the chemicals in this tobacco product

Chemicals have been linked to:

that researchers have linked to health problems. Research is on going to find out which chemicals
in tobacco and tobacco smoke cause harm.

Cancer
Lung Disease

There may be other health problems and chemicals that have not been discovered yet.
Tobacco companies test their cigarettes for these chemicals and report the amounts to the FDA.

Heart and Blood Vessel Problems

Please note: There is no safe tobacco product. Based on what we currently know, you can not

Reproductive Problems

tell your chance of developing a health problem by the number of chemicals or the amount of a
chemical in a tobacco product.

Addiction

TOBACCO

per gram

SMOKE

TOBACCO

ND
F

Amount
per gram
Per Gram

n

Acetaldehyde

n

P LµgA N TAcrolein
60 – 240

3 - 15 µg
per
cigarette

&

Acrylonitrile

n

FOUND IN

SMOKE

amount per
cigarette

n
n

3 - 4 ng

1-Aminonaphthalene

n

ND

2-Aminonaphthalene

n

170 - 370 mg
10 - 130 µg
PLANT
per
40 - 120 ng amount
F
gram of
FOUND IN

tobacco

amount per
gram of
tobacco

4-Aminobiphenyl

ND

&

Where do these chemicals
come from?
per gram

n

n

Benzene

n

n

n

Benzo[a]pyrene

n

F

1,3-Butadiene

n

n

n

F

Cadmium

n

n

n

12 - 50 µg

F

8.5 – 17.6 ng

Carbon monoxide

F

10 - 20 µg

Crotonaldehyde

n

F

10.3 -25 µg

Formaldehyde

n

450 - 1000 µg

Isoprene

n

0.1 – 1.6 µg

110 - 133 ng

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

n

11.3 – 26.7 mg

0.1-3.0 mg

Nicotine

0.9 – 6.9 µg

154 - 196 ng

N-Nitrosonornicotine (NNN)

F

ND

amount per
gram of
tobacco

per
cigarette

FOUND IN

PLANT

amount per
gram of
tobacco

mg= milligram
µg = microgram
ng = nanogram
pg= picogram

n

n

n

n
n

Toluene

n

The information is not currently available on the following chemicals.

F

Amount
Per Cigarette CHEMICAL
n

F

Acetamide

F

Acetone

F

Acrylamide

n

Aflatoxin B1

n

n

n

F

F

Anabasine

F

F

o-Anisidine

n

F

A-α-C (2-Amino-9H-pyrido[2,3-b]indole)

n

F

Benz[a]anthracene

n

F

Benz[j]aceanthrylene

n

F

Benzo[b]fluoranthene

n

n

F

Benzo[k]fluoranthene

n

n

F

Benzo[b]furan

n

F

Benzo[c]phenanthrene

n

F

F

Beryllium

n

F

F

Caffeic acid

n

F

F

Catechol

n

F

Chlorinated dioxins/furans

n

F

F

Chromium

n

F

F

Chrysene

n

n

F

F

Cobalt

n

n

F
F

F

FOUND IN

P L Afrom
NT
Many of these chemicals come
the tobacco leaf and the smoke.
The rest come from the filter, glue, ink,
paper and additives.

n

14 - 23 mg

per
cigarette

SMOKE

n

amount per
cigarette

SMOKE

TOBACCO

n

n

Ammonia
FOUND IN

n

S Arsenic
MOKE

F

Amount
Per Gram

per gram

n

FOUND IN

S M OFK E

41 - 62 ng

TOBACCO

The information is not currently
available

Amount per
cigarette
Per Cigarette
CHEMICAL
770 - 864 µg

Not Detected

n

n
n

n

Coumarin (banned in food)

A machine is used to test for these chemicals. The amount of chemical that gets into the body may be
higher or lower depending on how a person uses the tobacco product. Companies may use different tests to
measure these chemicals. Results may vary.

&

FOUND IN

SMOKE

amount per
cigarette

&

S

U.S. Food and Drug Administration

Logo Sheet 1298.01

TOBACCO

Tobacco Product: Brand X Cigarette
per gram

KEY
SMOKE

TOBACCO

Chemicals have been linked to:
Cancer

Amount
per gram
Per Gram

Amount per
cigarette
Per Cigarette CHEMICAL

F

Cresols (o-, m-, and p-cresol)
F
TCyclopenta[c,d]pyrene
FP L A N
amount per
gram of
SMOKE
tobacco
amount per
Dibenz[a,h]anthracene
F
cigarette

n

F

Dibenzo[a,e]pyrene

n

F

Dibenzo[a,h]pyrene

n

F

Dibenzo[a,i]pyrene

n

F

Dibenzo[a,l]pyrene

n

FOUND IN

SMOKE

per
cigarette

FOUND IN

PLANT

F

Lung Disease

amount per
gram of
tobacco

&
F

&

FOUND IN

FOUND IN

S 2,6-Dimethylaniline
MOKE
amount per
cigarette

n

n

Reproductive Problems
Addiction

n

F

Ethyl carbamate (urethane)

n

F

Ethylbenzene

n

F

Ethylene oxide

n

F

Furan

n

F

Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]
imidazole)

n

F

Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)

n

F

F

Hydrazine

n

F

F

Hydrogen cyanide

F

Indeno[1,2,3-cd]pyrene

n

F

IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)

n

F

Lead

n

F

MeA-α-C (2-Amino-3-methyl)-9H-pyrido[2,3-b]indole)

n

F

F

Mercury

n

F

F

Methyl ethyl ketone

F

5-Methylchrysene

n

F

F

Naphthalene

n

n

F

F

Nickel

n

n

F

F

Nitrobenzene

n

n

F

Nitromethane

n

F

2-Nitropropane

n

F

F

N-Nitrosodiethanolamine (NDELA)

n

F

F

N-Nitrosodiethylamine (NDEA)

n

F

F

N-Nitrosodimethylamine (NDMA)

n

F

F

N-Nitrosomethylethylamine

n

N-Nitrosomorpholine (NMOR)

n

F
F

F

F

F
n

N-Nitrosopiperidine (NPIP)

n

F

F

N-Nitrosopyrrolidine (NPYR)

n

F

N-Nitrososarcosine (NSAR)

n

F

Nornicotine

Not Detected
TOBACCO

The information is not currently
available

n

per gram

SMOKE

TOBACCO

n
n

Where do these chemicals
come from?
per gram

per
cigarette

FOUND IN

SMOKE

n

P L Afrom
NT
Many of these chemicals come
the tobacco leaf and the smoke.
The rest come from the filter, glue, ink,
paper and additives.
amount per
gram of
tobacco

n
n

per
cigarette

n

F

FOUND IN

PLANT

amount per
gram of
tobacco

mg= milligram
µg = microgram
ng = nanogram
pg= picogram

n

n
n

n

n

n

F

Phenol

F

PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]
pyridine)

n

F

F

Polonium-210

n

F

F

Propionaldehyde

F

F

Propylene oxide

n

F

F

Quinoline

n

F

F

Selenium

F

F

Styrene

n

F

F

2-Toluidine

n

F

Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)

n

F

Trp-P-2 (1-Methyl-3-amino-5H-pyrido[4,3-b]indole )

n

F

Uranium-235

n

n

F

Uranium-238

n

n

F

Vinyl acetate

n

n

F

Vinyl chloride

n

F

ND

n

n

F

F

Heart and Blood Vessel Problems

n

n
n

A machine is used to test for these chemicals. The amount of chemical that gets into the body may be
higher or lower depending on how a person uses the tobacco product. Companies may use different tests to
measure these chemicals. Results may vary.

&

FOUND IN

SMOKE

amount per
cigarette

&

S


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