Att 8 - Laboratory Component

Attachment 8

Laboratory Assessments

Attachment 8 – NHANES Laboratory Assessments

Attachment 8a - Laboratory Analytes by Age Group

Test Name	Sample	Matrix
Ages 1-2
Complete Blood Count	Full	Whole blood
Erythrocyte Folate	Full	Whole blood
Hepatitis B Surface Antibody (Anti-HBs) 2 years and older	Full	Serum
Serum Folate	Full	Serum
Vitamin D	Full	Serum
Ages 3-5
Complete Blood Count	Full	Whole blood
Erythrocyte Folate	Full	Whole blood
Fatty Acids (polyunsaturated, monounsaturated, and saturated)	Full	Serum
Hepatitis Profile**	Full	Serum
Serum Folate	Full	Serum
Vitamin D	Full	Serum
Ages 6-11
Albumin/Creatinine	Full	Urine
Caffeine	One-third	Urine
Cholesterol (Total)/ High Density Lipoprotein Cholesterol (HDL)	Full	Serum
Complete Blood Count	Full	Whole blood
Estradiol	Full	Serum
Erythrocyte Folate	Full	Whole blood
Fluoride, plasma	Full	Plasma EDTA
Fluoride, water	Full	Water
Fatty Acids (polyunsaturated, monounsaturated, and saturated)	Full	Plasma EDTA
Hepatitis Profile**	Full	Serum
Serum Folate	Full	Serum
Sex hormone binding globin	Full	Serum
Testosterone	Full	Serum
Tissue transglutaminase (TTG)/Endomysial antibody (EMA)	Full	Serum
Urine flow rate	Full	Urine
Vitamin D	Full	Serum
Ages 12-19
Albumin/Creatinine	Full	Urine
Biochemistry Profile*	Full	Serum
Caffeine	One-third	Urine
Chlamydia trachomatis (14-19 years)	Full	Urine
Cholesterol (Total)/ High Density Lipoprotein Cholesterol (HDL)	Full	Serum
Complete Blood Count	Full	Whole blood
Erythrocyte Folate	Full	Whole blood
Estradiol	Full	Serum
Fluoride, plasma	Full	Plasma EDTA
Fluoride, water	Full	Water
Glucose (Oral Glucose Tolerance Test)	One-half	Plasma Na2F
Glucose, fasting	One-half	Plasma Na2F
Glycohemoglobin	Full	Whole blood
Fatty Acids (polyunsaturated, monounsaturated, and saturated)	One-half	Serum
Hepatitis Profile**	Full	Serum
Herpes Simplex Virus (HSV) (14-19 years)	Full	Serum
Human Immunodeficiency Virus Antibody (18-19 years)	Full	Serum
Human Papilloma Virus (14-19 years)	Full	Serum
Human Papilloma Virus (Females and Males 14-19 years)	Full	Swab
Human Papilloma Virus (14-19 years)	Full	Rinse
Methylmalonic acid (MMA) (19 years)	Full	Serum
Insulin	One-half	Serum
Serum Folate	Full	Serum
Sex hormone binding globulin	Full	Serum
Testosterone	Full	Serum
Tissue transglutaminase (TTG)/Endomysial antibody (EMA)	Full	Serum
Triglycerides/Low Density Lipoprotein Cholesterol/Apolipoprotein B	One-half	Serum
Trichomonas vaginalis (14-19 years)	Full	Urine
Urine flow rate	Full	Serum
Vitamin D	Full	Serum
Vitamin B12 (19+ years)	Full	Serum
Ages 20 and older
Albumin/Creatinine	Full		Urine
Biochemistry Profile*	Full		Serum
Caffeine	One-third		Urine
Chlamydia trachomatis (20-39 years)	Full		Urine
Cholesterol (Total)/ High Density Lipoprotein Cholesterol (HDL)	Full		Serum
Complete Blood Count	Full		Whole blood
Erythrocyte Folate	Full		Whole blood
Estradiol	Full		Serum
Glucose (Oral Glucose Tolerance Test)	One-half		Plasma Na2F
Glucose, fasting	One-half		Plasma Na2F
Glycohemoglobin	Full		Whole blood
Fatty Acids (polyunsaturated, monounsaturated, and saturated)	One-half		Serum
Hepatitis Profile **	Full		Serum
Herpes Simplex Virus (HSV) (20-49 years)	Full		Serum
Human Immunodeficiency Virus antibody (20-59 years)	Full		Serum
Human Papilloma Virus (20-59 years)	Full		Serum
Human Papilloma Virus (Females and Males 20-59 years)	Full		Swab
Human Papilloma Virus (20-69 years)	Full		Rinse
Insulin	One-half		Serum
Methylmalonic acid (20+ years)	Full		Serum
Serum Folate	Full		Serum
Sex hormone binding globulin	Full		Serum
Testosterone	Full		Serum
Tissue transglutaminase (TTG)/Endomysial antibody (EMA)	Full		Serum
Triglycerides/Low Density Lipoprotein Cholesterol/Apolipoprotein B	One-half		Serum
Trichomonas vaginalis (20-59 years)	Full		Urine
Urine flow rate	Full		Urine
Vitamin B12 (19+ years)	Full		Serum
Vitamin D	Full		Serum
*Biochemistry Profile
Albumin
Alkaline phosphatase
Aspartate aminotransferase (AST)
Alanine aminotransferase (ALT)
Blood urea nitrogen (BUN)
Bicarbonate (HCO3)
Total calcium
Total cholesterol
Chloride
CPK
Creatinine
Globulin
Glucose
v-glutamyltransferase (GGT)
Iron
Potassium
Lactate dehydrogenase (LDH)
Sodium
Osmolality
Phosphorus
Total Bilirubin
Total protein
Triglycerides
Uric acid
**Hepatitis Profile
Hepatitis A antibody (Anti-HAV)
Hepatitis B Core antibody (Anti-HBc)
Hepatitis B Surface Antibody (Anti-HBs)
Hepatitis B Surface Antigen (HbsAg)
Hepatitis C Antibody (Anti-HCV)
Hepatitis C HCV genotype
Hepatitis C Ribonucleic Acid (HCV-RNA)
Anti-HCV Supplemental Test (RIBA)
Hepatitis D antibody (anti-HDV)
Hepatitis E antibody (anti-HEV)

Attachment 8 – NHANES Laboratory Assessments

Attachment 8b - Laboratory Analytes by Survey Year

All urine based and packed cells analyses are done on a 1/3 sample of participants ages 6 and older unless otherwise noted. All blood based (whole blood, serum, plasma) analyses are done on a 1/3 sample of participants ages 12 and older unless otherwise noted.

Chemical / Metabolite Name	Matrix		09-10	11-12		13-14
Tobacco Biomarkers: Cotinine and Nicotine Analogs
Cotinine0	serum		●	●		●
Cotinine	urine					●
Anabasine	urine					●
Anatabine	urine					●
Cotinine-n-oxide	urine					●
Hydroxycotinine	serum					●
Hydroxycotinine	urine					●
Norcotinine	urine					●
Menthol	urine					●
Nicotine	urine					●
Nicotine-1'N-oxide	urine					●
1-(3-Pyridyl)-1-butanol-4-carboxylic Acid	urine					●
1-(3-Pyridyl)-1-butanone-4-carboxylic Acid	urine					●
Nornicotine	urine					●
Tobacco Biomarkers: Aldehydes
Acetaldehyde	serum					●
Acrolein	serum					●
Benzaldehyde	serum					●
Butyraldehyde	serum					●
Crotonaldehyde	serum					●
Decanal	serum					●
Furaldehyde	serum					●
Heptanal	serum					●
n-Hexanal	serum					●
Isovaleraldehyde	serum					●
Nonanal	serum					●
2-Nonenal	serum					●
Octanal	serum					●
o-Tolualdehyde	serum					●
Pentanal	serum					●
Propionaldehyde	serum					●
Tobacco Biomarkers: Aromatic Amines
1-Aminonaphthalene	urine					●
2-Aminonaphthalene	urine					●
2-Aminobiphenyl	urine					●
3-Aminobiphenyl	urine					●
4-Aminobiphenyl	urine					●
Anisidine	urine					●
Benzidine	urine					●
2,6-Dimethylaniline	urine					●
o-Toluidine	urine					●
p-Toluidine	urine					●
Quinoline	urine					●
Tobacco Biomarkers: Heterocyclic Amines
Norharman	urine					●
Harman	urine					●
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1)	urine					●
1-Methyl-3-amino-5H-pyrido[4,3-b]indole (Trp-P-2)	urine					●
2-Amino-3-methyl-9H-pyriodo[2,3-b]indole (MeA-α-C)	urine					●
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (Ph1P)	urine					●
2-Amino-9H-pyrido[2,3-b]indole (A-α-C)	urine					●
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ)	urine					●
2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P1)	urine					●
2-Aminodipyrido[1,2-a:3',2'-d] imidazole (GLU-P2)	urine					●
Tobacco Biomarkers: TSNAs
4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanol (NNAL) 1	urine		●	●		●
N'-Nitrosanatabine (NAT) 1	urine					●
N'-Nitrosanabasine (NAB) 1	urine					●
4-(N-methylnitrosoamino)-4-(3-pyridyl) butanal (NNA) 1	urine					●
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) 1	urine					●
N'-Nitrosonornicotine (NNN) 1	urine					●
Tobacco Biomarkers: N-Nitrosamines
N-Nitrosodiethylamine (NDEA)	urine					●
N-nitrosodimethylamine (NDMA)	urine					●
N-Nitrosoethylmethylamine (NMEA)	urine					●
N-nitrosomorpholine (NMOR)	urine					●
N-Nitrosopiperidine (NPIP)	urine					●
N-Nitrosopyrrolidine (NPYR)	urine					●
Metals
Lead2	whole blood		●	●		●
Lead	urine		●	●		●
Cadmium2	whole blood		●	●		●
Cadmium	urine		●	●		●
Manganese2	whole blood			●		●
Selenium2	whole blood			●		●
Mercury (total) 2	whole blood		●	●		●
Mercury (ethyl) 2	whole blood			●		●
Mercury (methyl) 2	whole blood			●		●
Mercury (inorganic) 2	whole blood		●	●		●
Mercury	urine		●	●		●
Iodine	urine		●	●		●
Arsenic (total)	urine		●	●		●
Arsenous (III) acid	urine		●	●		●
Arsenic (V) acid	urine		●	●		●
Monomethylarsonic acid	urine		●	●		●
Dimethylarsinic acid	urine		●	●		●
Arsenobetaine	urine		●	●		●
Arsenocholine	urine		●	●		●
Trimethylarsine oxide	urine		●	●		●
Antimony	urine		●	●		●
Barium	urine		●	●		●
Cesium	urine		●	●		●
Cobalt	urine		●	●		●
Manganese	urine			●		●
Molybdenum	urine		●	●		●
Strontium	urine			●		●
Tin	urine			●		●
Thallium	urine		●	●		●
Tungsten	urine		●	●		●
Uranium	urine		●	●		●
Copper3	serum			●		●
Selenium3	serum			●		●
Zinc3	serum			●		●
Phthalates and Phthalate Alternatives
Mono-ethyl phthalate	urine		●	●		●
Mono-n-butyl phthalate	urine		●	●		●
Mono-iso-butyl phthalate	urine		●	●		●
Mono-benzyl phthalate	urine		●	●		●
Mono-2-ethylhexyl phthalate	urine		●	●		●
Mono-(2-ethyl-5-oxohexyl) phthalate	urine		●	●		●
Mono-(2-ethyl-5-hydroxyhexyl) phthalate	urine		●	●		●
Mono-(3-carboxypropyl) phthalate	urine		●	●		●
Mono-(2-ethyl-5-carboxypentyl) phthalate	urine		●	●		●
Mono-(2,6-dimethyl-6-carboxyhexyl) phthalate	urine		●	●		●
Mono-(2,7-dimethyl-7-carboxyheptyl) phthalate	urine		●	●		●
Cyclohexane 1,2-dicarboxylic acid, mono hydroxyisononyl ester (MINCH)	urine			● surplus		●
Polycyclic Aromatic Hydrocarbons
2-Hydroxyfluorene	urine		●	●		●
3-Hydroxyfluorene	urine		●	●		●
9-Hydroxyfluorene	urine		●	●		●
1-Hydroxyphenanthrene	urine		●	●		●
2-Hydroxyphenanthrene	urine		●	●		●
3-Hydroxyphenanthrene	urine		●	●		●
4-Hydroxyphenanthrene	urine		●	●		●
1-Hydroxypyrene	urine		●	●		●
1-Hydroxynapthalene (1-Naphthol)	urine		●	●		●
2-Hydroxynapthalene (2-Naphthol)	urine		●	●		●
Organophosphate Insecticides:  Dialkyl Phosphate Metabolites
Dimethylphosphate	urine		●	●		●
Dimethylthiophosphate	urine		●	●		●
Dimethyldithiophosphate	urine		●	●		●
Diethylphosphate	urine		●	●		●
Diethylthiophosphate	urine		●	●		●
Diethyldithiophosphate	urine		●	●		●
Organophosphate Insecticides: Specific Pesticides and Metabolites
Malathion dicarboxylic acid	urine		●	●		●
3,5,6-Trichloro-2-pyridinol	urine		●	●		●
2-Isopropyl-4-methyl-6-hydroxypyrimidine	urine		●	●		●
para-Nitrophenol	urine		●	●		●
Pyrethroid Pesticides
cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid	urine		●	●		●
trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid	urine		●	●		●
3-Phenoxybenzoic acid	urine		●	●		●
4-Fluoro-3-phenoxybenzoic acid	urine		●	●		●
cis-3-(2,2-Dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid	urine		●	●		●
Organochlorine Pesticides
Hexachlorobenzene	serum		Pool	Pool
beta-Hexachlorocyclohexane	serum		Pool	Pool
gamma-Hexachlorocyclohexane	serum		Pool	Pool
p,p'-DDT	serum		Pool	Pool
p,p'-DDE	serum		Pool	Pool
Oxychlordane	serum		Pool	Pool
trans-Nonachlor	serum		Pool	Pool
Mirex	serum		Pool	Pool
Other Pesticides
N,N-diethyl-3-methylbenzamide (DEET)	urine		●	●		●
N-ethyl-3-methylbenzamide (Desethyl DEET)	urine		●	●		●
N,N-diethyl-3-hydroxymethylbenzamide (Desethyl hydroxy DEET)	urine		●	●		●
2,5-Dichlorophenol	urine		●	●		●
Other Herbicides
2,4,5-Trichlorophenoxyacetic acid	urine		●	●		●
2,4-Dichlorophenoxyacetic acid	urine		●	●		●
2,4-Dichlorophenol	urine		●	●		●
Halogenated Phenolic Compounds
2,4,5-Trichlorophenol	urine		●	●
2,4,6-Trichlorophenol	urine		●	●
Pentachlorophenol	serum		●	●		●
5-Chloro-2-(2,4-dichlorophenoxy)-phenol (Triclosan)	serum		●	●
Perfluorinated Compounds
Perfluorooctanoic acid	serum		●	●		●
Perfluorooctane sulfonic acid	serum		●	●		●
Perfluorohexane sulfonic acid	serum		●	●		●
2-(N-Methyl-perfluorooctane sulfonamido) acetic acid	serum		●	●		●
Pefluorodecanoic acid	serum		●	●		●
Perfluorobutane sulfonic acid	serum		●	●		●
Perfluorononanoic acid	serum		●	●		●
Perfluoroundecanoic acid	serum		●	●		●
Environmental Phenols
Bisphenol A	urine		●	●		●
Benzophenone-3 (2-Hydroxy-4-methoxybenzophenone)	urine		●	●		●
Antiseptics
Triclocarban (TCC)	urine			●		●
Triclosan (2,4,4’-Trichloro-2’-hydroxyphenyl ether)	urine		●	●		●
Methyl paraben	urine		●	●		●
Ethyl paraben	urine		●	●		●
Propyl paraben	urine		●	●		●
Butyl paraben	urine		●	●		●
Polychlorinated Dibenzo-p-dioxins and Dibenzofurans
1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin (OCDD)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin (HpCDD)	serum		Pool	Pool		Pool
1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin (HxCDD)	serum		Pool	Pool		Pool
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (HxCDD)	serum		Pool	Pool		Pool
1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (HxCDD)	serum		Pool	Pool		Pool
1,2,3,7,8-Pentachlorodibenzo-p-dioxin (PeCDD)	serum		Pool	Pool		Pool
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8,9-Octachlorodibenzofuran (OCDF)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8-Heptachlorodibenzofuran (HpCDF)	serum		Pool	Pool		Pool
1,2,3,4,7,8,9-Heptachlorodibenzofuran (HpCDF)	serum		Pool	Pool		Pool
1,2,3,4,7,8-Hexachlorodibenzofuran (HxCDF)	serum		Pool	Pool		Pool
1,2,3,6,7,8-Hexachlorodibenzofuran (HxCDF)	serum		Pool	Pool		Pool
1,2,3,7,8,9-Hexachlorodibenzofuran (HxCDF)	serum		Pool	Pool		Pool
1,2,3,7,8-Pentachlorodibenzofuran (PeCDF)	serum		Pool	Pool		Pool
2,3,4,6,7,8-Hexachlorodibenzofuran (HxCDF)	serum		Pool	Pool		Pool
2,3,4,7,8-Pentachlorodibenzofuran (PeCDF)	serum		Pool	Pool		Pool
2,3,7,8-Tetrachlorodibenzofuran (TCDF)	serum		Pool	Pool		Pool
Polybrominated Dibenzo-p-dioxins and Dibenzofurans
2,3,7,8-Tetrabromorodienzo-p-dioxin (TBDD)	serum		Pool	Pool		Pool
1,2,3,7,8-Pentabromodibenzo-p-dioxin (PeBDD)	serum		Pool	Pool		Pool
1,2,3,4,7,8-Hexabromorodibenzo-p-dioxin (HxBDD)	serum		Pool	Pool		Pool
1,2,3,6,7,8-Hexabromodibenzo-p-dioxin (HxBDD)	serum		Pool	Pool		Pool
1,2,3,7,8,9-Hexabromodibenzo-p-dioxin (HxBDD)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8,9-Octabromodibenzo-p-dioxin (OBDD)	serum		Pool	Pool		Pool
2,3,7,8,-Tetrabromodibenzofuran (TBDF)	serum		Pool	Pool		Pool
1,2,3,7,8-Pentabromodibenzofuran (PeBDF)	serum		Pool	Pool		Pool
2,3,4,7,8-Pentabromodibenzofuran (PeBDF)	serum		Pool	Pool		Pool
1,2,3,4,7,8-Hexabromodibenzofuran (HxBDF)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8-Heptabromodibenzofuran (HpBDF)	serum		Pool	Pool		Pool
1,2,3,4,6,7,8,9-Octabromodibenzofuran (OBDF)	serum		Pool	Pool		Pool
Dioxin-like Polychlorinated Biphenyls - cPCBs
3,3',4,4'-Tetrachlorobiphenyl (PCB 77)	serum		Pool	Pool		Pool
3,4,4',5-Tetrachlorobiphenyl (PCB 81)	serum		Pool	Pool		Pool
3,3',4,4',5-Pentachlorobiphenyl (PCB 126)	serum		Pool	Pool		Pool
3,3',4,4',5,5'-Hexachlorobiphenyl (PCB 169)	serum		Pool	Pool		Pool
Dioxin-like Polychlorinated Biphenyls - mPCBs
2,3,3',4,4'-Pentachlorobiphenyl (PCB 105)	serum		Pool	Pool		Pool
2,3,3',4,4'-Pentachlorobiphenyl (PCB 114)	serum		Pool	Pool		Pool
2,3',4,4',5-Pentachlorobiphenyl (PCB 118)	serum		Pool	Pool		Pool
2',3,4,4',5-Pentachlorobiphenyl (PCB 123)	serum		Pool	Pool		Pool
2,3,3',4,4',5-Hexachlorobiphenyl (PCB 156)	serum		Pool	Pool		Pool
2,3,3',4,4',5'-Hexachlorobiphenyl (PCB 157)	serum		Pool	Pool		Pool
2,3',4,4',5,5'-Hexachlorobiphenyl (PCB 167)	serum		Pool	Pool		Pool
2,3,3’,4,4’,5,5’-Heptachlorobiphenyl (PCB 189)	serum		Pool	Pool		Pool
Non-dioxin-like Polychlorinated Biphenyls
2,4,4'-Trichlorobiphenyl (PCB 28)	serum		Pool	Pool		Pool
2,2'3,5'-Tetrachloro biphenyl (PCB 44)	serum		Pool	Pool		Pool
2,2',4,5'-Tetrachloro biphenyl (PCB 49)	serum		Pool	Pool		Pool
2,2',5,5'-Tetrachlorobiphenyl (PCB 52)	serum		Pool	Pool		Pool
2,3',4,4'-Tetrachlorobiphenyl (PCB 66)	serum		Pool	Pool		Pool
2,4,4',5-Tetrachlorobiphenyl (PCB 74)	serum		Pool	Pool		Pool
2,2’,3,4,5’-Pentachlorobiphenyl (PCB 87)	serum		Pool	Pool		Pool
2,2',4,4',5-Pentachlorobiphenyl (PCB 99)	serum		Pool	Pool		Pool
2,2',4,5,5'-Pentachlorobiphenyl (PCB 101)	serum		Pool	Pool		Pool
2,3,3’,4’,6-Pentachlorobiphenyl (PCB 110)	serum		Pool	Pool		Pool
2,2',3,3',4,4'-Hexachlorobiphenyl (PCB 128)	serum		Pool	Pool		Pool
2,2',3,4,4',5' and 2,3,3’,4,4’,6-Hexachlorobiphenyl (PCB 138 & 158)	serum		Pool	Pool		Pool
2,2',3,4',5,5'-Hexachlorobiphenyl (PCB 146)	serum		Pool	Pool		Pool
2,2’,3,4’,5’,6-Hexachlorobiphenyl (PCB 149)	serum		Pool	Pool		Pool
2,2’,3,5,5’,6-Hexachlorobiphenyl (PCB 151)	serum		Pool	Pool		Pool
2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153)	serum		Pool	Pool		Pool
2,2',3,3',4,4',5-Heptachlorobiphenyl (PCB 170)	serum		Pool	Pool		Pool
2,2',3,3',4,5,5'-Heptachlorobiphenyl (PCB 172)	serum		Pool	Pool		Pool
2,2',3,3',4,5',6'-Heptachlorobiphenyl (PCB 177)	serum		Pool	Pool		Pool
2,2',3,3',5,5',6-Heptachlorobiphenyl (PCB 178)	serum		Pool	Pool		Pool
2,2',3,4,4',5,5'-Heptachlorobiphenyl (PCB 180)	serum		Pool	Pool		Pool
2,2',3,4,4',5',6-Heptachlorobiphenyl (PCB 183)	serum		Pool	Pool		Pool
2,2',3,4',5,5',6-Heptachlorobiphenyl (PCB 187)	serum		Pool	Pool		Pool
2,2’,3,3’,4,4’,5,5’-Octachlorobiphenyl (PCB 194)	serum		Pool	Pool		Pool
2,2’,3,3’,4,4’,5,6-Octachlorobiphenyl (PCB 195)	serum		Pool	Pool		Pool
2,2’,3,3’,4,4’,5,6’ and 2,2’,3,4,4’,5,5’,6-Octachlorobiphenyl (PCB 196 & 203)	serum		Pool	Pool		Pool
2,2’,3,3’,4,5,5’,6-Octachlorobiphenyl (PCB 199) (previosuly PCB 201)	serum		Pool	Pool		Pool
2,2’,3,3’,4,4’,5,5’,6-Nonachlorobiphenyl (PCB 206)	serum		Pool	Pool		Pool
2,2',3,3',4,4',5,5',6,6'-Decachloro biphenyl (PCB 209)	serum		Pool	Pool		Pool
Hydroxylated Polychlorinated Biphenyls
2,3,3',4',5-pentachloro-4-biphenylol (4-HO-CB107) (PCB 105+118)	serum		Pool	Pool		Pool
2,2',3,4',5,5'-hexachloro-4-biphenylol (4-HO-CB146) (PCB 138+153)	serum		Pool	Pool		Pool
2,2',3,4',5,5,6'-heptachloro-4-biphenylol (4-HO-CB187) (PCB 187)	serum		Pool	Pool		Pool
Polybrominated Diphenyl Ethers
2,2',4’-Tribromodiphenyl ether (BDE 17)	serum		Pool	●		●
2,4,4’-Tribromodiphenyl ether (BDE 28)	serum		Pool	●		●
2,2’,4,4’-Tetrabromodiphenyl ether (BDE 47)	serum		Pool	●		●
2,3',4,4'-Tetrabromodiphenyl ether (BDE 66)	serum		Pool	●		●
2,2’,3,4,4’-Pentabromodiphenyl ether (BDE 85)	serum		Pool	●		●
2,2’,4,4’,5-Pentabromodiphenyl ether (BDE 99)	serum		Pool	●		●
2,2’,4,4’,6-Pentabromodiphenyl ether (BDE 100)	serum		Pool	●		●
2,2’,4,4’,5,5’-Hexabromobiphenyl (BB 153)	serum		Pool	●		●
2,2’,4,4’,5,6’-Hexabromodiphenyl ether (BDE 154)	serum		Pool	●		●
2,2’,4,4’,5,5’-Hexabromodiphenyl ether (BDE 153)	serum		Pool	●		●
2,2’,3,4,4’,5’,6-Heptabromodiphenyl ether (BDE 183)	serum		Pool	●		●
2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE 209)	serum		Pool	●		●
Polychlorinated Naphthalenes
1,2,3,4-Tetrachlorinated naphthalene (PCN 27)	serum		Pool	Pool		Pool
1,2,3,5,7- and 1,2,4,6,7-Pentachlorinated naphthalene (PNC 52 & 60)	serum		Pool	Pool		Pool
1,2,3,4,5,7- and 1,2,3,5,6,8-Hexachlorinated naphthalene (PNC 64 & 68)	serum		Pool	Pool		Pool
1,2,3,4,6,7- and 1,2,3,5,6,7-Hexachlorinated naphthalene (PNC 66 & 67)	serum		Pool	Pool		Pool
1,2,3,5,7,8-Hexachlorinated naphthalene (PCN 69)	serum		Pool	Pool		Pool
1,2,3,4,5,6,7-Heptachlorinated naphthalene (PCN 73)	serum		Pool	Pool		Pool
Volatile Organic Compounds (VOCs)
1,1,1-Trichloroethane4	whole blood		●	●		●
1,1,2,2-Tetrachloroethane4	whole blood		●	●
1,1,2-Trichloroethane4	whole blood		●	●
1,1-Dichloroethane4	whole blood		●	●
1,1-Dichloroethene4	whole blood		●	●
1,2-dibromo-3-chloropropane4	whole blood		●	●
1,2-Dichlorobenzene4	whole blood		●	●		●
1,2-Dichloroethane4	whole blood		●	●		●
1,2-Dichloropropane4	whole blood		●	●
1,3-Dichlorobenzene4	whole blood		●	●		●
1,4-Dichlorobenzene4	whole blood		●	●		●
2,5-Dimethylfuran4	whole blood		●	●		●
Acrylonitrile4	whole blood		●	●		●
Benzene4	whole blood		●	●		●
Bromodichloromethane4	whole blood		●	●		●
Bromoform4	whole blood		●	●		●
Carbon Tetrachloride4	whole blood		●	●		●
Chlorobenzene4	whole blood		●	●		●
Chloroform4	whole blood		●	●		●
Chloroform4	water		●	●		●
cis-1,2-Dichloroethene4	whole blood		●	●
Dibromochloromethane4	whole blood		●	●		●
Dibromomethane4	whole blood		●	●
Ethylbenzene4	whole blood		●	●		●
Furan4	whole blood		●	●		●
Hexachloroethane4	whole blood		●	●
m-/p-Xylene4	whole blood		●	●		●
Methylene Chloride4	whole blood		●	●		●
Methyl-tert-Butyl Ether (MTBE) 4	whole blood		●	●		●
Nitrobenzene4	whole blood		●	●		●
o-Xylene4	whole blood		●	●		●
Styrene4	whole blood		●	●		●
Tetrachloroethene4	whole blood		●	●		●
Toluene4	whole blood		●	●		●
trans-1,2-Dichloroethene4	whole blood		●	●
Trichloroethene4	whole blood		●	●		●
1,4-Dioxane4	whole blood		●	●		●
1,2-Dibromoethane4	whole blood		●	●		●
n-Hexane4	whole blood		●	●		●
Nitromethane4	whole blood		●	●		●
1,1,1,2-Tetrachloroethane4	whole blood		●	●		●
Cumene/isopropylbenzene4	whole blood		●	●		●
1,2,3-Trichloropropane4	whole blood		●	●		●
Ethyl acetate4	whole blood					●
1-Bromopropane/Propyl bromide4	whole blood					●
Methylcyclopentane4	whole blood					●
Cyclohexane4	whole blood					●
Benzonitrile4	whole blood					●
AAA-Trifluorotoluene/α,α,α-Trifluorotoluene4	whole blood					●
Chloroethane4	whole blood					●
Methyl isobutyl ketone4	whole blood					●
Tetrahydrofuran4	whole blood					●
Vinyl bromide4	whole blood					●
Heptane4	whole blood					●
Octane4	whole blood					●
Volatile Organic Compound Metabolites (VOC metabolites) (28)
N-Acetyl-S-(2-carbamoylethyl)-L-cysteine	urine			●		●
N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine	urine			●		●
2-Aminothiazoline-4-carboxylic acid	urine			●		●
N-Acetyl-S-(benzyl)-L-cysteine	urine			●		●
N-Acetyl-S-(n-propyl)-L-cysteine	urine			●		●
N-Acetyl-S- (2-carboxyethyl)-L-Cysteine	urine			●		●
N-acetyl-S-(2-cyanoethyl)-L-cysteine	urine			●		●
N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine	urine			●		●
N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine	urine			●		●
N-Acetyl-S- (3,4-dihydroxybutyl)-L-Cysteine	urine			●		●
N-Acetyl-S-(dimethylphenyl)-L-Cysteine	urine			●		●
N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine	urine			●		●
N-Acetyl-S- (2-hydroxyethyl)-L-cysteine	urine			●		●
N-Acetyl-S- (3-hydroxypropyl)-L-Cysteine	urine			●		●
N-Acetyl-S- (2-hydroxypropyl)-L-Cysteine	urine			●		●
N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine	urine			●		●
Mandelic acid	urine			●		●
2-Methylhippuric acid	urine			●		●
3-Methylhippuric acid & 4-methylhippuric acid	urine			●		●
N-Acetyl-S- (1-hydroxyMethyl-2-Propenyl)-L-Cysteine	urine			●		●
N-Acetyl-S- (2-hydroxy-3-butenyl)-L-Cysteine	urine			●		●
N-Acetyl-S- (4-hydroxy-2-butenyl)-L-Cysteine	urine			●		●
t,t-Muconic acid	urine			●		●
N-Acetyl-S-(phenyl-2-hydroxyethyl)-L-cysteine	urine			●		●
Phenylglyoxylic acid	urine			●		●
N-Acetyl-S-(phenyl)-L-cysteine	urine			●		●
N-Acetyl-S-(trichlorovinyl)-L-cysteine	urine			●		●
N-Acetyl-S(2hydroxy3methyl3butenyl)-Lcys	urine					●
N-Acetyl-S(2hydroxy2methyl3butenyl)-Lcys	urine					●
2-Thioxothiazolidine-4-carboxylic acid	urine			●		●
Heterocyclic Amine (HCA) Hemoglobin Adducts
2-Amino-3-methylimidazo[4,5-f]quinoline (Hb-IQ)	packed cells					●
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (Hb-PhIP)	packed cells					●
2-Amino-9H-pyrido[2,3-b]indole (Hb-A-α-C)	packed cells					●
(2-Amino-3-methyl)-9H-pyrido[2,3-b]indole (Hb-MeA-α-C)	packed cells					●
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Hb-Trp-P-1)	packed cells					●
1-Methyl-3-amino-5H-pyrido[4,3-b]indole (Hb-Trp-P-2)	packed cells					●
2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Hb-Glu-P1)	packed cells					●
2-Aminodipyrido[1,2-a:3',2'-d]imidazole (Hb-Glu-P-2)	packed cells					●
Other
Perchlorate	urine		●	●		●
Thiocyanate	urine		●	●		●
Nitrate	urine		●	●		●
Ethylene Oxide	packed cells					●
Acrylamide	packed cells		●			●
Formaldehyde	packed cells					●
Glycidamide	packed cells		●			●
0All participants ages 3 and older 1All participants ages 6 and older
2 Participants ages 1 -11 years and all participants 12+ years
3 Participants ages 6+ years, one-third sample

⁴Participants-ages 12+ years, one-half sample