60-day notice

81556

Federal Register / Vol. 80, No. 250 / Wednesday, December 30, 2015 / Notices

obtained by contacting: Attn. Invention
Development and Marketing Unit,
Technology Transfer Center, National
Cancer Institute, 9609 Medical Center
Drive, Mail Stop 9702, Rockville, MD,
20850–9702, Tel. 240–276–5515 or
email [email protected]. A
signed Confidential Disclosure
Agreement may be required to receive
copies of the patent applications.
SUPPLEMENTARY INFORMATION:

Technology description follows.
Title of invention: A Novel FullyHuman Anti-CD30 Chimeric Antigen
Receptor for Treatment of CD30+
Lymphoma.
Description of Technology: Chimeric
antigen receptors (CARs) are hybrid
proteins that consist of two major
components: A targeting domain and a
signaling domain. The targeting domain
allows T cells which express the CAR to
selectively recognize and bind to
diseased cells that express a particular
protein. Once the diseased cell is bound
by the targeting domain of the CAR, the
signaling domain of the CAR activates
the T cell, thereby allowing it to kill the
diseased cell. This is a promising new
therapeutic approach known as
adoptive cell therapy (ACT).
Researchers at the National Cancer
Institute’s Experimental Transplantation
and Immunology Branch developed a
CAR that recognizes human tumor
necrosis factor receptor superfamily
member 8 (TNFRSF8, also known as
CD30). The expression of CD30 is
deregulated in a variety of human
cancers, including many lymphomas.
By creating a CAR that recognizes CD30,
it may be possible to treat these cancers
using adoptive cell therapy.
Potential Commercial Applications
—Treatment of human cancers
associated with expression of CD30 or
variants thereof
—Specific cancers include: NonHodgkins Lymphomas, Hodgkin’s
Lymphomas, several solid malignancies

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Value Proposition
—Human components are less likely
to cause adverse or neutralizing immune
response in patients
—Targeted therapies decrease nonspecific killing of healthy cells and
tissues, resulting in fewer off-target sideeffects and healthier patients
Development Stage
In vivo/Lead Validation.
Inventor(s)
Jim N. Kochenderfer, M.D. (NCI).

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Intellectual Property
HHS Reference No. E–001–2016/0–US–
01
US Provisional Application 62/241,896
(HHS Reference No. E–001–2016/0–
US–01) filed October 15, 2015 entitled
‘‘A Novel Fully-Human Anti-CD30
Chimeric Antigen Receptor for
Treatment of CD30+ Lymphoma’’
Licensing Opportunity: Researchers at
the NCI seek licensees for a chimeric
antigen receptor (CAR) that recognizes
human tumor necrosis factor receptor
superfamily member 8 (TNFRSF8, also
known as CD30) for use as a cancer
therapeutic.
Contact Information
Requests for copies of the patent
application or inquiries about licensing
and/or research collaboration and codevelopment opportunities should be
sent to John D. Hewes. Ph.D., email:
[email protected].
Dated: December 22, 2015.
Thomas M. Stackhouse,
Associate Director, Technology Transfer
Center, National Cancer Institute.
[FR Doc. 2015–32879 Filed 12–29–15; 8:45 am]

Institutes of Health, 7201 Wisconsin Avenue,
Suite 2c212, Bethesda, MD 20892, 301–402–
7705, [email protected].
(Catalogue of Federal Domestic Assistance
Program Nos. 93.866, Aging Research,
National Institutes of Health, HHS)
Dated: December 23, 2015.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2015–32773 Filed 12–29–15; 8:45 am]
BILLING CODE 4140–01–P

DEPARTMENT OF HOMELAND
SECURITY
U.S. Citizenship and Immigration
Services
[OMB Control Number 1615–0014]

Agency Information Collection
Activities: Affidavit of Support, Form
I–134; Extension, Without Change, of a
Currently Approved Collection
U.S. Citizenship and
Immigration Services, Department of
Homeland Security.
ACTION: 60-day notice.
AGENCY:

BILLING CODE 4140–01–P

The Department of Homeland
Security (DHS), U.S. Citizenship and
Immigration (USCIS) invites the general
public and other Federal agencies to
comment upon this proposed extension
of a currently approved collection of
information. In accordance with the
Paperwork Reduction Act (PRA) of
1995, the information collection notice
is published in the Federal Register to
obtain comments regarding the nature of
the information collection, the
categories of respondents, the estimated
burden (i.e. the time, effort, and
resources used by the respondents to
respond), the estimated cost to the
respondent, and the actual information
collection instruments.
DATES: Comments are encouraged and
will be accepted for 60 days until
February 29, 2016.
ADDRESSES: All submissions received
must include the OMB Control Number
1615–0014 in the subject box, the
agency name and Docket ID USCIS–
2006–0072. To avoid duplicate
submissions, please use only one of the
following methods to submit comments:
(1) Online. Submit comments via the
Federal eRulemaking Portal Web site at
http://www.regulations.gov under
e-Docket ID number USCIS–2006–0072;
(2) Email. Submit comments to
[email protected];
(3) Mail. Submit written comments to
DHS, USCIS, Office of Policy and
Strategy, Chief, Regulatory Coordination
SUMMARY:

DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute on Aging; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute on
Aging Special Emphasis Panel; Alzheimer’s
Center.
Date: February 4, 2016.
Time: 3:00 p.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Bethesda North Marriott Hotel &
Conference Center, 5701 Marinelli Road,
North Bethesda, MD 20852.
Contact Person: Jeannette L. Johnson,
Ph.D., National Institutes on Aging, National

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Federal Register / Vol. 80, No. 250 / Wednesday, December 30, 2015 / Notices
Division, 20 Massachusetts Avenue
NW., Washington, DC 20529–2140.
FOR FURTHER INFORMATION CONTACT:
USCIS, Office of Policy and Strategy,
Regulatory Coordination Division, Laura
Dawkins, Chief, 20 Massachusetts
Avenue NW., Washington, DC 20529–
2140, telephone number 202–272–8377
(This is not a toll-free number.
Comments are not accepted via
telephone message). Please note contact
information provided here is solely for
questions regarding this notice. It is not
for individual case status inquiries.
Applicants seeking information about
the status of their individual cases can
check Case Status Online, available at
the USCIS Web site at http://
www.uscis.gov, or call the USCIS
National Customer Service Center at
800–375–5283 (TTY 800–767–1833).
SUPPLEMENTARY INFORMATION:

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Comments
You may access the information
collection instrument with instructions,
or additional information by visiting the
Federal eRulemaking Portal site at:
http://www.regulations.gov and enter
USCIS–2006–0072 in the search box.
Regardless of the method used for
submitting comments or material, all
submissions will be posted, without
change, to the Federal eRulemaking
Portal at http://www.regulations.gov,
and will include any personal
information you provide. Therefore,
submitting this information makes it
public. You may wish to consider
limiting the amount of personal
information that you provide in any
voluntary submission you make to DHS.
DHS may withhold information
provided in comments from public
viewing that it determines may impact
the privacy of an individual or is
offensive. For additional information,
please read the Privacy Act notice that
is available via the link in the footer of
http://www.regulations.gov.
Written comments and suggestions
from the public and affected agencies
should address one or more of the
following four points:
(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility;
(2) Evaluate the accuracy of the
agency’s estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and

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(4) Minimize the burden of the
collection of information on those who
are to respond, including through the
use of appropriate automated,
electronic, mechanical, or other
technological collection techniques or
other forms of information technology,
e.g., permitting electronic submission of
responses.
Overview of This Information
Collection
(1) Type of Information Collection:
Extension, Without Change, of a
Currently Approved Collection.
(2) Title of the Form/Collection:
Affidavit of Support.
(3) Agency form number, if any, and
the applicable component of the DHS
sponsoring the collection: I–134; USCIS.
(4) Affected public who will be asked
or required to respond, as well as a brief
abstract: Primary: Individuals or
households. This information collection
is necessary to determine if at the time
of application into the United States, the
applicant is likely to become a public
charge.
(5) An estimate of the total number of
respondents and the amount of time
estimated for an average respondent to
respond: The estimated total number of
respondents for the information
collection I–134 is 18,460 and the
estimated hour burden per response is
1.5 hours.
(6) An estimate of the total public
burden (in hours) associated with the
collection: The total estimated annual
hour burden associated with this
collection is 27,960 hours.
(7) An estimate of the total public
burden (in cost) associated with the
collection: There is no estimated total
annual cost burden associated with this
collection of information.
Dated: December 23, 2015.
Laura Dawkins,
Chief, Regulatory Coordination Division,
Office of Policy and Strategy, U.S. Citizenship
and Immigration Services, Department of
Homeland Security.
[FR Doc. 2015–32876 Filed 12–29–15; 8:45 am]

ACTION:

81557

Public land order.

This order partially revokes
the withdrawal created by Public Land
Order No. 1378 insofar as it affects 21.91
acres reserved for the use of the United
States Forest Service as the Sunshine
Campground. This order also opens the
land to appropriation and use of all
kinds under the public land laws,
except for the United States mining
laws.

SUMMARY:

The effective date is: December
30, 2015.
FOR FURTHER INFORMATION CONTACT:
Valerie Hunt, U.S. Forest Service, Rocky
Mountain Region 2, 303–275–5071; or
Steve Craddock, Bureau of Land
Management, Colorado State Office,
303–239–3707; or write: Land Tenure
Program Lead, BLM Colorado State
Office, 2850 Youngfield Street,
Lakewood, Colorado 80215–7093.
Persons who use a telecommunications
device for the deaf (TDD) may call the
Federal Information Relay Service
(FIRS) at 1–800–877–8339 to contact the
above individuals. The FIRS is available
24 hours a day, 7 days a week, to leave
a message or question. You will receive
a reply during normal business hours.
SUPPLEMENTARY INFORMATION: The
United States Forest Service determined
that a portion of the land withdrawn
and reserved for the Sunshine
Campground is not needed for picnic or
recreation use, and has requested a
partial revocation of the withdrawal.
The land will remain segregated from
the United States mining laws due to a
pending land exchange proposal.
DATES:

Order
By virtue of the authority vested in
the Secretary of the Interior by Section
204 of the Federal Land Policy and
Management Act of 1976, 43 U.S.C.
1714, it is ordered as follows:
1. The withdrawal created by Public
Land Order No. 1378 (22 FR 240 (1957))
is hereby revoked in part as to the
following described land:

BILLING CODE 9111–97–P

Uncompahgre National Forest

DEPARTMENT OF THE INTERIOR

New Mexico Principal Meridian
T. 42 N., R. 9 W.,
Sec. 20, lot 11.
The area described contains 21.91 acres in
San Miguel County.

Bureau of Land Management
[LLCO–9230000–L1440000–ET0000; COC
013297]

Public Land Order No. 7847; Partial
Revocation of a Public Land Order No.
1378; Colorado
Bureau of Land Management,
Department of the Interior.

AGENCY:

PO 00000

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2. At 9 a.m. on December 30, 2015,
subject to valid existing rights, the
provisions of existing withdrawals,
other segregations of record, and the
requirements of applicable law, the land
described in Paragraph 1 is hereby
opened to such forms of disposition as
may be made of National Forest System

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