| Nationally Notifiable Conditions in NNDSS Application |
| Anaplasma phagocytophilum |
| Anthrax |
| Babesiosis |
| Botulism |
| Brucellosis |
| Campylobacteriosis |
| Central line associated bloodstream infection |
| Chancroid |
| Chlamydia trachomatis infection |
| Cholera (toxigenic Vibrio cholerae O1 or O139) |
| Coccidioidomycosis |
| Cryptosporidiosis |
| Cyclosporiasis |
| Diphtheria |
| Ehrlichia chaffeensis |
| Ehrlichia ewingii |
| Ehrlichiosis/Anaplasmosis, undetermined |
| Free-living amoeba infections |
| Giardiasis |
| Gonorrhea |
| Haemophilus influenzae, invasive disease |
| Hansen disease (Leprosy) |
| Hantavirus pulmonary syndrome |
| Hemolytic uremic syndrome postdiarrheal |
| Hepatitis A, acute |
| Hepatitis B virus infection, chronic |
| Hepatitis B, acute |
| Hepatitis B, virus infection perinatal |
| Hepatitis C |
| Hepatitis E, acute |
| Influenza-associated pediatric mortality |
| Invasive Pneumococcal Disease (IPD) |
| Legionellosis |
| Leptospirosis |
| Listeriosis |
| Lyme disease |
| Malaria |
| Measles |
| Melioidosis |
| Meningococcal disease (Neisseria meningitidis) |
| Mumps |
| Novel influenza A virus infections, initial detections of |
| Pertussis |
| Plague |
| Poliomyelitis, paralytic |
| Poliovirus infection, nonparalytic |
| Psittacosis (Ornithosis) |
| Q fever, acute |
| Q fever, chronic |
| Rabies, animal |
| Rabies, human |
| Rubella |
| Rubella, congenital syndrome |
| Salmonellosis |
| Severe Acute Respiratory Syndrome (SARS)-associated Coronavirus disease (SARS-CoV) |
| Shiga toxin-producing Escherichia coli (STEC) |
| Shigellosis |
| Smallpox |
| Spotted Fever Rickettsiosis |
| Streptococcal toxic-shock syndrome |
| Syphilis |
| Tetanus |
| Toxic-shock syndrome (staphylococcal) |
| Trichinellosis |
| Tularemia |
| S. Typhi infection |
| Vancomycin-intermediate Staphylococcus aureus (VISA) |
| Vancomycin-resistant Staphylococcus aureus (VRSA) |
| Varicella (Chickenpox) |
| Vibriosis (non-cholera Vibrio species infections) |
| Viral hemorrhagic fevers |
| Hantavirus infection, non-Hantavirus Pulmonary Syndrome |
| Arboviral diseases |
| Candida auris |
| Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) |
| Tuberculosis (TB) Disease |
| Carbon Monoxide Poisoning |
| S. Paratyphi infection |