| Nationally Notifiable Conditions in NNDSS Application |
| Anaplasma phagocytophilum |
| Anthrax |
| Babesiosis |
| Botulism |
| Brucellosis |
| California serogroup virus neuroinvasive and non-neuroinvasive disease |
| Campylobacteriosis |
| Central line associated bloodstream infection |
| Chancroid |
| Chlamydia trachomatis infection |
| Cholera (toxigenic Vibrio cholerae O1 or O139) |
| Coccidioidomycosis |
| Cryptosporidiosis |
| Cyclosporiasis |
| Dengue fever (DF), Dengue hemorrhagic fever (DHF), Dengue shock syndrome (DSS) |
| Diphtheria |
| Eastern equine encephalitis virus neuroinvasive and non-neuroinvasive disease |
| Ehrlichia chaffeensis |
| Ehrlichia ewingii |
| Ehrlichiosis/Anaplasmosis, undetermined |
| Free-living amoeba |
| Giardiasis |
| Gonorrhea |
| Haemophilus influenzae, invasive disease |
| Hansen disease (Leprosy) |
| Hantavirus pulmonary syndrome |
| Hemolytic uremic syndrome postdiarrheal |
| Hepatitis A, acute |
| Hepatitis B virus infection, chronic |
| Hepatitis B, acute |
| Hepatitis B, virus infection perinatal |
| Hepatitis C virus, past or present |
| Hepatitis C, acute |
| Hepatitis E, acute |
| Infections by free living amoeba |
| Influenza-associated pediatric mortality |
| Jamestown Canyon virus, neuroinvasive and non-neuroinvasive disease |
| Legionellosis |
| Leptospirosis |
| Listeriosis |
| Lyme disease |
| Malaria |
| Measles (rubeola), total |
| Melioidosis |
| Meningococcal disease (Neisseria meningitidis) |
| Mumps |
| Novel influenza A virus infections, initial detections of |
| Pertussis |
| Plague |
| Poliomyelitis, paralytic |
| Poliovirus infection, nonparalytic |
| Powassan virus neuroinvasive and non-neuroinvasive disease |
| Psittacosis (Ornithosis) |
| Q fever, acute |
| Q fever, chronic |
| Rabies, animal |
| Rabies, human |
| Rubella |
| Rubella, congenital syndrome |
| Salmonellosis |
| Severe Acute Respiratory Syndrome (SARS)-associated Coronavirus disease (SARS-CoV) |
| Shiga toxin-producing Escherichia coli (STEC) |
| Shigellosis |
| Smallpox |
| Spotted Fever Rickettsiosis |
| St. Louis encephalitis virus neuroinvasive and non-neuroinvasive disease |
| Streptococcal toxic-shock syndrome |
| Streptococcus pneumoniae, invasive disease (IPD) (all ages) |
| Syphilis |
| Tetanus |
| Toxic-shock syndrome (staphylococcal) |
| Trichinellosis |
| Tularemia |
| Typhoid fever (caused by Salmonella typhi) |
| Vancomycin-intermediate Staphylococcus aureus (VISA) |
| Vancomycin-resistant Staphylococcus aureus (VRSA) |
| Varicella (Chickenpox) |
| Vibriosis (non-cholera Vibrio species infections) |
| Viral hemorrhagic fevers |
| West Nile virus neuroinvasive and non-neuroinvasive disease |
| Western equine encephalitis virus neuroinvasive and non-neuroinvasive disease |
| Yellow fever |